Prostaglandin Receptor Antagonist
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CRTh2 antagonist 4
0 ImagesCat. No.: HY-116890CAS No.: 916046-55-4CRTh2 antagonist 4 (compound 58) is an inhibitor (IC50: 212 nM) of TH2 lymphocyte (CRTH2 or DP2) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases.
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Grapiprant-d4
0 ImagesCat. No.: HY-16781SSynonyms: CJ-023423-d4; RQ-00000007-d4; AAT-007-d4Grapiprant-d4 (CJ-023423-d4) is the deuterium labeled Grapiprant (HY-16781). Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor with IC50 value of 35 nM and Ki value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment[3] .
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TG11-77 hydrochloride
0 ImagesCat. No.: HY-158659CAS No.: 2550393-38-7TG11-77 hydrochloride is a potent, selective, orally active and brain permeant EP2 antagonist, with a KB of 9.7 nM. TG11-77 hydrochloride inhibits PGE2-induced human EP2 receptor activation. TG11-77 hydrochloride exhibits anti-inflammatory activity. TG11-77 hydrochloride reduces delayed mortality and memory deficit.
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EP4 receptor antagonist 8
0 ImagesCat. No.: HY-178465CAS No.: 3068255-86-4EP4 receptor antagonist 8 is an orally active EP4 antagonist (human EP4 IC50 = 6.40 nM). EP4 receptor antagonist 8 significantly reduced paw and joint swelling, inflammatory cell infiltration, cartilage damage, pannus formation, and joint bone erosion in arthritis (AIA) mice in a dose-dependent manner. EP4 receptor antagonist 8 can be used for the study of inflammatory pain.
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ONO 3708
0 ImagesCat. No.: HY-106105CAS No.: 102191-05-9ONO 3708 is a TXA2/PGH2 receptor antagonist that can inhibit the binding properties of U46619 in unactivated intact human platelets, with an IC50 value of 38 nM.
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CRTh2 antagonist 1
0 ImagesCat. No.: HY-112265CAS No.: 1379445-54-1CRTh2 antagonist 1 is a CRTh2 antagonist with an IC50 of 89 nM.
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SC-42867
0 ImagesCat. No.: HY-105894CAS No.: 102251-91-2SC-42867 is a PGE2 antagonist. SC-42867 can be metabolized in the liver through oxidative N-dealkylation, aromatic hydroxylation, and binding reactions. SC-42867 can be used for research on metabolic conditions.
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Prostaglandin F2α dimethyl amine
0 ImagesCat. No.: HY-114761CAS No.: 67508-09-2Prostaglandin F2α dimethyl amine is a Prostaglandin F2α (HY-12956) derivative. Prostaglandin F2α dimethyl amine is an antagonist for Prostaglandin F receptor (FP). Prostaglandin F2α dimethyl amine blocks the cardiovascular responses induced by orexin and Arachidonic acid (HY-109590).
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TG6-129
0 ImagesCat. No.: HY-18970CAS No.: 1164464-14-5TG6-129 is a selective antagonist of the EP2 receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages.
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AM-461
0 ImagesCat. No.: HY-13214CAS No.: 1203503-64-3AM-461 is a DP2 receptor (Prostaglandin Receptor) antagonist. AM-461 can be used for the researches of inflammation and immunology, such as asthma.
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TP receptor antagonist-2
0 ImagesCat. No.: HY-160664CAS No.: 1448452-22-9TP receptor antagonist-2 (example 7n) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 5.64 and 5.27 μM for TPα and TPβ, respectively. TP receptor antagonist-2 inhibits platelet aggregation.
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EP3 antagonist 7
0 ImagesCat. No.: HY-157496CAS No.: 740850-59-3EP3 antagonist 7 (Compound II) is an EP3 receptor antagonist. EP3 antagonist 7 can be used in the study of itching, pain, dysuria or stress disorders.
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AGN 225660
0 ImagesCat. No.: HY-183037CAS No.: 1354060-46-0AGN 225660 is a multi-prostanoid receptor antagonist with human IC50 values of 70, 70, 5, 220 and 180 nM for EP1, EP4, TP, DP1, FP. AGN 225660 inhibits secretion of RANTES, IL-8, MCP-1, IL-12p70, and IL-23. AGN 225660 exhibits good ocular bioavailability and reduces ocular inflammation linked to phacoemulsification surgery and uveitis.
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CAY10595
0 ImagesCat. No.: HY-118180CAS No.: 916047-16-0CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.
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Z-335 sodium
0 ImagesCat. No.: HY-19249CAS No.: 146731-14-8Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively.
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EP3 antagonist 5
0 ImagesCat. No.: HY-157494CAS No.: 499147-44-3EP3 antagonist 5 (Compound 22) is an EP3 receptor antagonist with an IC50 value of 67 nM.
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CXT29
0 ImagesCat. No.: HY-179246CXT29 is an orally active COX-2 inhibitor and a thromboxane A2 receptor (TP) antagonist. CXT29 exhibits COX inhibitory activity and selectivity, with IC50 values of 13 and 722 nM for COX-2 and COX-1 respectively. CXT29 inhibits platelet aggregation induced by U-46619 (HY-108566) (a TP agonist), with an IC50 of 96 nM. CXT29 effectively inhibits the production of TXB₂ and PGE₂, significantly reducing platelet aggregation and inflammatory pain in mice. CXT29 can be used for research on inflammatory pain and cardiovascular diseases.
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TPα/β antagonist-1
0 ImagesCat. No.: HY-186042CAS No.: 899789-84-5TPα/β antagonist-1 is a TXA2 receptor α (TPα) and TPβ antagonist with IC50s of 1.52 nM and 0.79 nM, respectively. TPα/β antagonist-1 inhibits U-46619 (HY-108566)-induced intracellular calcium mobilization, and imhibits platelet aggregation. TPα/β antagonist-1 can be used for the research of cardiovascular disease.
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L 640035
0 ImagesCat. No.: HY-118488CAS No.: 77167-93-2L 640035 is athromboxaneantagonist.
