TPα/β antagonist-1 

TPα/β antagonist-1 is a TXA2 receptor α (TPα) and TPβ antagonist with IC₅₀s of 1.52 nM and 0.79 nM, respectively. TPα/β antagonist-1 inhibits U-46619 (HY-108566)-induced intracellular calcium mobilization, and imhibits platelet aggregation. TPα/β antagonist-1 can be used for the research of cardiovascular disease^[1].

TPα/β antagonist-1 (compound 7d) binds to both TPα and TPβ receptors with preferential affinity for TPβ (IC₅₀ TPα = 1.52 nM, IC₅₀ TPβ = 0.79 nM)^[1].
TPα/β antagonist-1 antagonizes U-46619 (HY-108566)-mediated calcium mobilization with greater potency for TPβ (IC₅₀ TPα = 600.71 nM, IC₅₀ TPβ = 70.15 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

433.48

C₂₀H₂₃N₃O₆S

899789-84-5

O=C(NC1CCCCC1)NS(=O)(C2=CC([N+]([O-])=O)=CC=C2OC3=CC=C(C=C3)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hanson J, et al. Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. J Med Chem. 2006;49(12):3701-3709.  [Content Brief]