TPα/β antagonist-1
TPα/β antagonist-1 is a TXA2 receptor α (TPα) and TPβ antagonist with IC50s of 1.52 nM and 0.79 nM, respectively. TPα/β antagonist-1 inhibits U-46619 (HY-108566)-induced intracellular calcium mobilization, and imhibits platelet aggregation. TPα/β antagonist-1 can be used for the research of cardiovascular disease.
For research use only. We do not sell to patients.
- CAS No.: 899789-84-5
- Formula: C20H23N3O6S
- Molecular Weight:433.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
TPα 1.52 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
0.79 nM
Compound: 7d
|
Displacement of [3H]SQ-29548 from TPbeta receptor (long isoform) expressed in COS7 cells at 1 uM
Displacement of [3H]SQ-29548 from TPbeta receptor (long isoform) expressed in COS7 cells at 1 uM
|
[PMID: 16759113] |
TPα/β antagonist-1 (compound 7d) binds to both TPα and TPβ receptors with preferential affinity for TPβ (IC50 TPα = 1.52 nM, IC50 TPβ = 0.79 nM)[1].
TPα/β antagonist-1 antagonizes U-46619 (HY-108566)-mediated calcium mobilization with greater potency for TPβ (IC50 TPα = 600.71 nM, IC50 TPβ = 70.15 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 899789-84-5
-
Molecular Weight 433.48
-
Formula C20H23N3O6S
-
SMILES
O=C(NC1CCCCC1)NS(=O)(C2=CC([N+]([O-])=O)=CC=C2OC3=CC=C(C=C3)C)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)