Reverse Transcriptase
Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.
Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
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Reverse Transcriptase Related Products (278)
Related Products (278)
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PNU‐142721
0 ImagesCat. No.: HY-15380CAS No.: 185220-03-5PNU-142721 is a reverse transcriptase inhibitor and PXR agonist that effectively inhibits various type I HIV variants.
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Phosphonoacetic acid (Standard)
0 ImagesCat. No.: HY-128744RCAS No.: 4408-78-0Phosphonoacetic acid Standard is the analytical standard of Phosphonoacetic acid (HY-128744). This product is intended for research and analytical applications. Phosphonoacetic acid is a potent antiviral agent. Phosphonoacetic acid inhibits a variety of herpesviruses, orthopoxviruses, and retroviruses. Phosphonoacetic acid strongly inhibits viral and cellular DNA polymerase, reverse transcriptase, and terminal deoxynucleotidyl transferase activities in a non-competitive or uncompetitive manner by binding to the pyrophosphate site of the enzyme. Phosphonoacetic acid is useful for research related to lymphoid leukemia, herpesvirus infection, and vaccinia virus skin lesions.
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NNRT-IN-13
0 ImagesCat. No.: HY-178341NNRT-IN-13 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor that directly inhibiting HIV-1 reverse transcriptase (IC₅₀ = 0.25 μM). NNRT-IN-13 exhibits excellent antiviral activity against wild-type HIV-1 (EC₅₀ = 0.0046 μM) and a broad spectrum of drug-resistant mutants. NNRT-IN-13 exhibits favorable in vivo metabolic and safety profiles. NNRT-IN-13 can be used for human immunodeficiency virus (HIV) research.
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Emtricitabine-13C,15N2
0 ImagesCat. No.: HY-17427S2CAS No.: 1217820-69-3Synonyms: BW1592-13C,15N2Emtricitabine-13C,15N2 (BW1592-13C,15N2) is a 13C- and 15N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.
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Inophyllum B
0 ImagesCat. No.: HY-142074CAS No.: 41135-06-2Synonyms: (+)-Inophyllum BInophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica.
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NNRT-IN-4
0 ImagesCat. No.: HY-162720NNRT-IN-4 (Compound 10p) is an inhibitor for non-nucleoside reverse transcriptase (NNRT) with an IC50 of 0.713 µM for HIV-1 RT. NNRT-IN-4 exhibits antiviral efficacy, inhibits HIV-1 wildtype and mutant strains with EC50 of 6-63 nM. NNRT-IN-4 exhibits a slight inhibitory activities against hERG (IC50=25.9 µM) and CYP enzymes (IC50>50 µM). NNRT-IN-4 exhibits good tolerability and safety in mice (2 g/kg).
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NNRT-IN-17
0 ImagesCat. No.: HY-189211NNRT-IN-17 is a non-nucleoside HIV-1 Reverse Transcriptase inhibitor with an IC50 of 0.095 μM. NNRT-IN-17 exerts its inhibitory effect by binding to the NNRTI binding pocket and adjacent sites, and exhibits antiviral activity against wild-type and multiple NNRTI-resistant mutant strains. NNRT-IN-17 can be used for the study of HIV-1 infection (AIDS).
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Nevirapine-d4
0 ImagesCat. No.: HY-10570SCAS No.: 1051418-95-1Nevirapine-d4 is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM.
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ALizarin complexone dihydrate
0 ImagesCat. No.: HY-W320523CAS No.: 455303-00-1ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens.
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UC-84
0 ImagesCat. No.: HY-105489CAS No.: 135812-04-3Synonyms: NSC-615985UC-84 (NSC-615985) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity.
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Tivirapine
0 ImagesCat. No.: HY-106918CAS No.: 137332-54-8Synonyms: R86183; TIBO R 86183
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(R)-Efavirenz
0 ImagesCat. No.: HY-10572ACAS No.: 154801-74-8Synonyms: (R)-DMP 266; (R)-EFV; (R)-L-743726(R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms.
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4'-Ethynyl-2'-deoxyadenosine
0 ImagesCat. No.: HY-125810CAS No.: 306305-07-74'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Adefovir-d4
0 ImagesSynonyms: GS-0393-d4; PMEA-d4Adefovir-d4 is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.
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UC-38
0 ImagesCat. No.: HY-105491CAS No.: 135812-34-9Synonyms: NSC-629243UC-38 (NSC-629243) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity.
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GB-1a
0 ImagesCat. No.: HY-136972ACAS No.: 19360-72-6Synonyms: Biflavanone GB-1aGB-1a (Biflavanone GB-1a) is a biflavanone HIV-1 reverse transcriptase inhibitor (IC50=236 μM), with an EC50 of 38.0 μM for HIV-1 replication. GB-1a can block the conversion of HIV-1 genomic RNA to DNA and can be used in research related to AIDS (HIV-1 infection). GB-1a can be naturally extracted from the heartwood of Garcinia multiflora Champ.
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NNRT-IN-8
0 ImagesCat. No.: HY-172996NNRT-IN-8 (compound 9K) is a potent non-nucleoside reverse transcriptase inhibitor with EC50 values of 0.0014, 0.0041, 0.0077 µM for WT HIV-1, K103N, E138K, respectively.
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α-Rubromycin
0 ImagesCat. No.: HY-119787CAS No.: 27267-69-2Synonyms: Collinomycinα-Rubromycin (Collinomycin) is an antibiotic isolated from the mycelia of Streptomyces collinus. α-Rubromycin also acts as a DNA polymerase inhibitor, with an IC50 of 0.91 μM against bovine mammalian DNA polymerase. α-Rubromycin binds to the active region of DNA polymerase β, competes with nucleotide substrates for binding, and interferes with template-DNA interactions. α-Rubromycin inhibits the activities of telomerase, retroviral reverse transcriptase and terminal deoxynucleotidyl transferase, as well as the growth of Staphylococcus aureus. α-Rubromycin can be used in studies related to bacterial infections.
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Phenoxan
0 ImagesCat. No.: HY-N21815CAS No.: 134332-63-1Phenoxan is an inhibitor of cytochrome b and NADH: ubiquinone oxidoreductase. It exerts anti-HIV, antifungal, and cytotoxic effects by inhibiting the electron transport chain, the activity of HIV-1 Reverse Transcriptase, and viral replication. Phenoxan can be used in studies of HIV-1 infection and fungal infections.
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K-5a2
0 ImagesCat. No.: HY-173427CAS No.: 1810730-10-9K-5a2 is the non-isotopic form of ZK-316 (HY-173427S). ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC50 value ranging from 0.99 to 75.1 nM. ZK-316 can be used in the study of HIV.
