SARS-CoV
SARS coronavirus
SARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS). CoVs are enveloped viruses with a positive-sense, single-stranded RNA and can cause health-threatening outbreaks by targeting human respiratory system, including not only SARS, but also Middle East respiratory syndrome (MERS) and SARS-CoV-2 (the cause of COVID-19).
CoVs have four main structural proteins: spike(S), membrane (M), envelope (E), and nucleocapsid (N) proteins. An S protein mediates the CoV entry into host cells by attaching to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), followed by fusion between virus and host cell membranes. Genome replication and subgenomic RNA transcription after entry carry on with the participation of many nonstructural proteins such as Mpro (main protease or 3CLpro), PLpro (papain-like protease) and RdRp (RNA-dependent RNA polymerase). Then the structural proteins are translated, assembled into mature virions, and released via vesicles by exocytosis. It is worth mentioning that a protease called TMPRSS2 (transmembrane protease, serine 2) play important roles throughout the whole life of CoVs (such as attachment, assembling and release) by cleaving S protein. All the proteins and subcellular structures participated in the life cycle of CoVs are promising targets for treatment of disease caused by CoVs.
All Product Categories
-
SARS-CoV Related Products (1208)
Related Products (1208)
-
Recombinant Proteins (196)
-
Pamaqueside
0 ImagesCat. No.: HY-105086CAS No.: 150332-35-7Synonyms: CP148623Pamaqueside (CP148623) is a cholesterol absorption inhibitor and a potent binder of the SARS-CoV-2 receptor-binding domain (RBD), which may inhibit viral cellular entry. Pamaqueside can be utilized in metabolic and antiviral research.
-
M56-S2 iodide
0 ImagesCat. No.: HY-155416CAS No.: 1101867-17-7M56-S2 iodide is a SARS-CoV-2 Mpro inhibitor (IC50=4.0 μM). M56-S2 iodide showed good oral bioavailability and low toxicity in ADMET prediction. M56-S2 iodide has good drug potential and can be used in antiviral (such as SARS-CoV-2) research.
-
ZINC61142882
0 ImagesCat. No.: HY-149319CAS No.: 3034181-87-5ZINC61142882 is an inhibitor of the SARS-CoV-2 Nsp14 N7-Methyltransferase (IC50: 6 μM).
-
FWM-4
0 ImagesCat. No.: HY-144799CAS No.: 2757194-03-7FWM-4 is a potent SARS-COV-2 NSP13 helicase enzyme inhibitor.
-
ZINC4497834
0 ImagesCat. No.: HY-169256CAS No.: 767310-01-0ZINC4497834 is an inhibitor of SARS-CoV-2 major protease Mpro. ZINC4497834 can be used in anti-COVID19 research.
-
SARS-CoV-2 3CLpro-IN-5
0 ImagesCat. No.: HY-151535CAS No.: 2913186-57-7SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor of 3C-like protease (3CLpro). SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CLpro with an IC50 value of 3.8 nM. SARS-CoV-2 3CLpro-IN-5 has 9.0% oral bioavailability (BA). SARS-CoV-2 3CLpro-IN-5 can be used for the research of coronavirus disease 2019 (COVID-19).
-
MERS-CoV-IN-4
0 ImagesCat. No.: HY-184669CAS No.: 2740494-38-4MERS-CoV-IN-4 is an orally active antiviral inhibitor targeting the MERS-CoV spike (S) protein, with an IC50 of 0.009 μM in Huh-7 cells, and Kd values of 7.72 μM for the full-length S protein and 5.09 μM for S-RBD. MERS-CoV-IN-4 inhibits viral entry, and suppresses MERS-CoV pseudoviruses and live viruses in vitro. MERS-CoV-IN-4 reduces pulmonary viral loads in hDPP4 transgenic mice. MERS-CoV-IN-4 can be used for research on Middle East respiratory syndrome coronavirus infection.
-
Hispidulin 4'-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N8205CAS No.: 244285-12-9Hispidulin 4'-O-β-D-glucopyranosid, a natural compound, may serve as a potential COVID-19 main protease inhibitor.
-
SARS-CoV-2 3CLpro-IN-4
0 ImagesCat. No.: HY-147805CAS No.: 2505241-31-4SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.
-
SARS-CoV-2-IN-30 disodium
0 ImagesCat. No.: HY-151278ASARS-CoV-2-IN-30 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-30 disodium exhibits antiviral activity with IC50s of 0.6 μM and 6.9 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-30 disodium induces liposomal membrane disruption with an EC50 value of 6.9 μM.
-
HR2-18
0 ImagesCat. No.: HY-P5398CAS No.: 742695-60-9HR2-18 is a biological active peptide， with inhibition of SARS-CoV penetration into cells.
-
Tipranavir-d5
0 ImagesCat. No.: HY-15148S2CAS No.: 1126619-17-7Synonyms: PNU-140690-d5Tipranavir-d5 (PNU-140690-d5) is the deuterium labeled Tipranavir (HY-15148). Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM. Tipranavir inhibits SARS-CoV-2 3CLpro activity.
-
TO-195 (hydrochlorid)
0 ImagesCat. No.: HY-19195CAS No.: 151328-91-5TO-195 hydrochlorid is a protease inhibitor targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). TO-195 hydrochlorid is promising for research of coronavirus disease 2019 (COVID-19).
-
(rel)-Lopinavir-d8
0 ImagesCat. No.: HY-14588SCAS No.: 1322625-54-6Synonyms: (rel)-ABT-378-d8(rel)-Lopinavir-d8 ((rel)-ABT-378-d8) is the deuterium labeled Lopinavir (HY-14588). Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.
-
DHODH-IN-31
0 ImagesCat. No.: HY-178156Purity: 99.55%DHODH-IN-31 is a human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.59 μM. DHODH-IN-31 exhibits antiviral activity. DHODH-IN-31 can be used for the research of infection, such as SARS-CoV-2.
