CD28 Ligand

SAR-442257 is a trispecific T-cell engager and monoclonal antibody that binds to CD38, CD3 and CD28. SAR-442257 can target and bind to CD3 and CD28 on T cells, as well as CD38 expressed on tumor cells. SAR-442257 mediates T-cell activation, enhances T-cell activity, induces T-cell degranulation, and drives cytotoxicity against multiple myeloma cells. SAR-442257 functions via CD38 expression, and its in vitro activity correlates with CD38 expression on the surface of multiple myeloma cells. SAR-442257 can be used in studies related to multiple myeloma and relapsed/refractory multiple myeloma.

Anti-Mouse CD28 Antibody (E18) is an anti-mouse CD28 monoclonal antibody. Anti-Mouse CD28 Antibody (E18) blocks B7/CD80/CD86 costimulatory signaling through competitive binding to the CD28 receptor, thereby inhibiting effector T cell activation and expansion while promoting regulatory T cell (Tregs) activity and reducing the release of pro-inflammatory cytokines. Anti-Mouse CD28 Antibody (E18) can be used for research on colon adenocarcinoma, Listeria infection, myocardial infarction, allergic asthma, and acute graft-versus-host disease.