2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endothelin-Converting Enzyme (ECE)
  5. Endothelin-Converting Enzyme (ECE) Inhibitor

Endothelin-Converting Enzyme (ECE) Inhibitor

Endothelin-Converting Enzyme (ECE) Isoform Comparison

Endothelin-Converting Enzyme (ECE) Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-120148A
    SM19712
    		Inhibitor 99.0%
    SM19712 serves as an inhibitor of the nonpeptide endothelin converting enzyme.
  • HY-178732
    AB-22
    		Inhibitor
    AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis.
  • HY-107762
    CGS35066
    		Inhibitor
    CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively.
  • HY-119545
    PD159790
    		Inhibitor
    PD159790 is a selective endothelin-converting enzyme-1 (ECE-1) inhibitor, with an EC50 of 28.1 μM.
  • HY-14474
    CGS 26303
    		Inhibitor
    CGS 26303 is an endothelin-converting enzyme (ECE) inhibitor. CGS 26303 increases the expression of endothelin-converting enzyme-1 in endothelial cells. CGS 26303 attenuates cerebral vasospasm in a rabbit subarachnoid hemorrhage model. CGS 26303 improves birth survival and alleviates pulmonary hypoplasia in newborn rats in a rat model of congenital diaphragmatic hernia. CGS 26303 can be used for research on cardiovascular and cerebrovascular diseases and congenital diaphragmatic hernia.