1. Signaling Pathways
  2. Apoptosis
    Autophagy
    Immunology/Inflammation
  3. FKBP
  4. FKBP Modulator

FKBP Modulator

FKBP Modulators (4):

Cat. No. Product Name Effect Purity
  • HY-112210
    Shield-1
    Modulator 99.52%
    Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD).
  • HY-13992
    AP20187
    Modulator 99.88%
    AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
  • HY-153806
    RapaBlock
    Modulator ≥98.0%
    RapaBlock is a potent, non-immunosuppressive and brain-impermeable FKBP12 ligand.
  • HY-126316
    Zapalog
    Modulator 98.16%
    Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis.