2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glyoxalase (GLO)

Glyoxalase (GLO)

The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many tissues, playing a pathogenic role in the progression of molecular and cellular aging.

The glyoxalase system consists of two cooperating enzymes named Glyoxalase 1 (Glo1) and Glyoxalase 2 (Glo2). Glo1 converts a non-enzymatically formed hemithioacetal, the adduct between an intracellular thiol such as glutathione (GSH) and a metabolically produced α-ketoaldehyde such as MG, into a thioester product . In the case of MG and GSH, S-D-lactoylglutathione is the product. Glo2 hydrolyzes this thioester into D-lactate and regenerates the intracellular thiol GSH. Glo1 and Glo2 work in tandem to convert cytoxic MG into D-lactate.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-N12255
    COTC
    		Inhibitor
    COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC50 = 18 µg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.
    COTC
  • HY-181980
    SPB07393SC
    		Inhibitor
    SPB07393SC is a glyoxalase-I (Glo-I) inhibitor with an IC50 of 11.1 μM. SPB07393SC is applicable for cancer research.
    SPB07393SC
  • HY-124824
    Methyl gerfelin
    		Inhibitor 99.9%
    Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class.
    Methyl gerfelin
  • HY-148216
    HBPC–GSH
    		Inhibitor
    HBPC-GSH is a glyoxalase (Glo) inhibitor (cGloI IC50=0.6 μM; cGloII IC50=1.6 μM), a glutathione derivative. HBPC-GSH can be used in antimalarial research.
    HBPC–GSH
  • HY-146657
    4BAB
    		Inhibitor
    4BAB (compound 29) is an irreversible glyoxalase I (GLO1) inhibitor. 4BAB has anticancer effects.
    4BAB
Cat. No. 상품명 / Synonyms Application Reactivity