2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PANK
  5. PanK3 Isoform
  6. PanK3 Modulator

PanK3 Modulator

PanK3 Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-159509
    Claziprotamidum
    		Modulator
    Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase (PANK) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 (KD = 97 pM; IC50 = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A (HY-128851) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia.