TBK1/IKKε-IN-1
TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.
For research use only. We do not sell to patients.
- CAS No.: 2058264-32-5
- Formula: C28H26N4O5
- Molecular Weight:498.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TBK1 100 nM (IC50) |
IKKε 100 nM (IC50) |
IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2058264-32-5
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Molecular Weight 498.53
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Formula C28H26N4O5
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SMILES
O=C(C1=CC(OC)=C(C2=CC3=NC=CC(C4=CC=C(OC5CCOCC5)C(C#N)=C4)=C3O2)N=C1)N(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TBK1/IKKε-IN-1 Related Classifications
HY-U00457 Related Classifications
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