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  4. Aceclofenac methyl ester

Aceclofenac methyl ester (Impurity-D) is the impurity found during the Aceclofenac (HY-B0634). Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID) with analgesic and anti-inflammatory properties.

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Aceclofenac methyl ester

Aceclofenac methyl ester Chemical Structure

CAS No. : 139272-66-5

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Aceclofenac methyl ester Related Antibodies

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Description

Aceclofenac methyl ester (Impurity-D) is the impurity found during the Aceclofenac (HY-B0634). Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID) with analgesic and anti-inflammatory properties[1].

Molecular Weight

368.21

Formula

C17H15Cl2NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC(OC)=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (135.79 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7158 mL 13.5792 mL 27.1584 mL
5 mM 0.5432 mL 2.7158 mL 5.4317 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7158 mL 13.5792 mL 27.1584 mL 67.8960 mL
5 mM 0.5432 mL 2.7158 mL 5.4317 mL 13.5792 mL
10 mM 0.2716 mL 1.3579 mL 2.7158 mL 6.7896 mL
15 mM 0.1811 mL 0.9053 mL 1.8106 mL 4.5264 mL
20 mM 0.1358 mL 0.6790 mL 1.3579 mL 3.3948 mL
25 mM 0.1086 mL 0.5432 mL 1.0863 mL 2.7158 mL
30 mM 0.0905 mL 0.4526 mL 0.9053 mL 2.2632 mL
40 mM 0.0679 mL 0.3395 mL 0.6790 mL 1.6974 mL
50 mM 0.0543 mL 0.2716 mL 0.5432 mL 1.3579 mL
60 mM 0.0453 mL 0.2263 mL 0.4526 mL 1.1316 mL
80 mM 0.0339 mL 0.1697 mL 0.3395 mL 0.8487 mL
100 mM 0.0272 mL 0.1358 mL 0.2716 mL 0.6790 mL
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Aceclofenac methyl ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aceclofenac methyl ester139272-66-5Drug IntermediateDrug Iintermediateosteoarthritisankylosing spondylitisrheumatoid arthritisInhibitorinhibitorinhibit

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