Acetylleucine-d10
Acetylleucine-d10 (N-Acetyl-DL-leucine-d10) is the deuterium labeled Acetylleucine (HY-B1442). Acetylleucine (N-Acetyl-DL-leucine), orally active compound, can be used for the research of acute vestibular vertigo, cerebellar ataxia and nystagmus.
For research use only. We do not sell to patients.
- Formula: C8H5D10NO3
- Molecular Weight:183.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 99-15-0
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Molecular Weight 183.27
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Formula C8H5D10NO3
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SMILES
CC(NC(C(O)=O)([2H])C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O
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Synonyms
N-Acetyl-DL-leucine-d10
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Feil K, et, al. Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus. Cerebellum. 2016 Feb;15(1):38-42. [Content Brief]
[2]. Clément G, et, al. Effects of vestibular training on motion sickness, nystagmus, and subjective vertical. J Vestib Res. 2007;17(5-6):227-37. [Content Brief]
[3]. Günther L, et al. N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus. PLoS One. 2015 Mar 24;10(3):e0120891. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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