1. Metabolic Enzyme/Protease
  2. Tryptophan Hydroxylase
  3. ACT-678689

ACT-678689 

Cat. No.: HY-19572
Handling Instructions

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM.

For research use only. We do not sell to patients.

ACT-678689 Chemical Structure

ACT-678689 Chemical Structure

CAS No. : 1783256-96-1

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Description

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

IC50 & Target

IC50: 8 nM (TPH)[1]

In Vitro

TPH comprises two isoforms: TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS), while TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets[1].

Molecular Weight

565.04

Formula

C₂₃H₂₂ClFN₆O₄S₂

CAS No.

1783256-96-1

SMILES

CS(=O)(NC1=NC(Cl)=C(OCC(N2CCC3=C(N4C(SC(C)=N4)=N3)[[email protected]@H]2C5=CC=C(C)C=C5F)=O)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ACT-678689ACT678689ACT 678689Tryptophan HydroxylaseInhibitorinhibitorinhibit

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