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Cat. No.: HY-W1142093

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ActRIIB-IN-4

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice.

For research use only. We do not sell to patients.

CAS No.: 3039974-41-6
Formula: C₂₂H₂₃N₅O₂
Molecular Weight:389.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-4 Chemical Structure

CAS No.: 3039974-41-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
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Biological Activity

Description

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC₅₀ of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice^[1].

All TGF-β Receptor Isoforms :

In Vitro

ActRIIB-IN-4 (0.625-10 μM) exerts a significant reversing effect on C2C12 myotube atrophy, with a reversal rate of 100.3% at 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ActRIIB-IN-4 (10 mg/kg; i.p.) significantly enhances muscle grip strength in C26 tumor cachexia mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3039974-41-6
Molecular Weight 389.45
Formula C₂₂H₂₃N₅O₂
SMILES

C1(C2=CC=C(OCCN3CCOCC3)C=C2)=CN=C(NC=C4C5=NNC=C5)C4=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dong, et al. 7-azaindole compounds, preparation method therefor, and use thereof. WO2024114661A1. WIPO (PCT). 2023-11-29.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vivo
Chemical Information
Purity & Documentation
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ActRIIB-IN-4

All TGF-β Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ActRIIB-IN-4 Related Classifications

HY-W1142093 Related Classifications