Alagebrium bromide
Based on 6 publication(s) in Google Scholar
Alagebrium bromide is an analog of Alagebrium Chloride (HY-106024B), a glucose cross-link blocker. Alagebrium Chloride disrupts glucose cross-links and may improve ventricular and arterial compliance. Alagebrium Chloride improves left ventricular diastolic filling and has the potential to inhibit diastolic heart failure (DHF).
For research use only. We do not sell to patients.
- CAS No.: 181069-80-7
- Formula: C13H14BrNOS
- Molecular Weight:312.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Alagebrium bromide
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Biological Activity
Chemical Information
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CAS No. 181069-80-7
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Molecular Weight 312.23
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Formula C13H14BrNOS
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SMILES
O=C(C1=CC=CC=C1)C[N+]2=CSC(C)=C2C.[Br-]
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Synonyms
ALT711 bromide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Biomaterials
Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model. [Abstract]2025 Jun 13:324:123504. PMID: 40543324 -
Free Radic Biol Med
APOE4 impairs Nrf2-PINK1/Parkin-dependent mitochondrial clearance through disrupted antioxidant and mitophagy signaling. [Abstract]2025 Nov 21:243:245-259. PMID: 41275935 -
Mol Med
D-mannose promotes diabetic wound healing through inhibiting advanced glycation end products formation in keratinocytes. [Abstract]2025 Jan 18;31(1):15. PMID: 39827347 -
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Am J Transl Res
Alagebrium targets the miR-27b/TSP-1 signaling pathway to rescue Nε-carboxymethyl-lysine-induced endothelial dysfunction. [Abstract]2019 Mar 15;11(3):1569-1580. PMID: 30972183
Alagebrium bromide purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2019 Mar 15;11(3):1569-1580. [Abstract]
Western blotting analysis of TSP-1 protein expression, and results show that TSP-1 expression in HUVECs treated with ALT-711 under CML-BSA condition is enhanced by miR-27b inhibitor.
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Cell Biomater
Diabetic hyperglycemia-induced glycation regulates tumor vasculature integrity via NF-κB-mediated GM-CSF secretion by tumor cells. [Abstract]2025 Aug 26:100186. PMID: 41058997
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)