ALK2-IN-6
ALK2-IN-6 (Compound 14a) is a selective ALK2 inhibitor, with an IC50 of 9 nM. ALK2-IN-6 can be used in the research of diffuse intrinsic pontine glioma.
For research use only. We do not sell to patients.
- CAS No.: 2600795-23-9
- Formula: C26H31N3O3
- Molecular Weight:433.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
ALK2 9 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>5000 nM
Compound: 14a
|
Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual luciferase reporter assay
Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual luciferase reporter assay
|
[PMID: 32787083] |
| HEK293 | IC50 |
56 nM
Compound: 14a
|
Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay
Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay
|
[PMID: 32787083] |
Chemical Information
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CAS No. 2600795-23-9
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Molecular Weight 433.54
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Formula C26H31N3O3
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SMILES
CN(CC1)CCN1C(C=C2)=CC=C2C3=C(C)C(C4=CC(OC)=C(C(OC)=C4)OC)=CN=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)