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Cat. No.: HY-176453

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Allobetulone

(Synonyms: N066-0059)

Allobetulone (N066-0059) is a TMEM16A inhibitor (IC₅₀: 0.24 µM). Allobetulone (N066-0059) can be used in anti-cancer research.

For research use only. We do not sell to patients.

CAS No.: 28282-22-6
Formula: C₃₀H₄₈O₂
Molecular Weight:440.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Allobetulone Chemical Structure

CAS No.: 28282-22-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Allobetulone (N066-0059) is a TMEM16A inhibitor (IC₅₀: 0.24 µM). Allobetulone (N066-0059) can be used in anti-cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]
BJ	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]
BXPC-3	GI₅₀	>10 μg/mL Compound: 18	Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 24694263]
CCRF-CEM	IC₅₀	>50 μM Compound: 3b	Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTS assay	[PMID: 27236068]
CCRF-CEM	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]
CEM-DNR	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human CEM-DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human CEM-DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]
DU-145	GI₅₀	>10 μg/mL Compound: 18	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 24694263]
HCT-116	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]
K562	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]
KM-20L2	GI₅₀	>10 μg/mL Compound: 18	Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 24694263]
MCF7	GI₅₀	>10 μg/mL Compound: 18	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 24694263]
MRC5	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]
NCI-H460	GI₅₀	>10 μg/mL Compound: 18	Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 24694263]
SF-268	GI₅₀	>10 μg/mL Compound: 18	Cytotoxicity against human SF268 cells after 48 hrs by SRB assay Cytotoxicity against human SF268 cells after 48 hrs by SRB assay	[PMID: 24694263]
U2OS	IC₅₀	>50 μM Compound: 7a	Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay	[PMID: 36174412]

Chemical Information

CAS No. 28282-22-6
Molecular Weight 440.70
Formula C₃₀H₄₈O₂
SMILES

C[C@]12[C@@](CC[C@@]3([H])[C@]2(CC[C@]4([H])[C@@]3(CCC(C4(C)C)=O)C)C)([H])[C@]5([H])[C@@]6(CO[C@@]5([H])C(C)(CC6)C)CC1
Synonyms

N066-0059
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sangkhawasi M, et al. Identification of novel TMEM16A blockers through integrated virtual screening, molecular dynamics, and experimental studies. Sci Rep. 2025 Apr 29;15(1):15065. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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