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製品番号: HY-126017

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Aminopyridine 2

Aminopyridine 2 is an irreversible, selective, and orally active myeloperoxidase (MPO) inhibitor, with an IC₅₀ of 0.16 μM and a K_i of 24 μM against human MPO. Aminopyridine 2 is applicable to research on chronic inflammatory diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2411643-58-6
分子式: C₁₃H₁₃BrN₄O
分子量:321.18

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aminopyridine 2 構造式

CAS 番号: 2411643-58-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
プロトコル (1)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

Glutathione Peroxidase アイソフォーム固有の製品をすべて表示 :

GPX1
GPX4

体外実験

Aminopyridine 2 (2 h) inhibits the activity of human MPO in plasma, with an apparent IC₅₀ of 1.9 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-∞	Bioavailability
Mice^[1]	10 mg/kg	p.o.	11884 nM	1.3 h	58440 nM·h/mL	51 %
Rat^[1]	10 mg/kg	p.o.	20844 nM	0.4 h	133162 nM·h/mL	~100 %
Dog^[1]	10 mg/kg	p.o.	19486 nM	2.3 h	335615 nM·h/mL	~100 %

体内実験

Aminopyridine 2 (2.5-100 mg/kg; p.o.; single administration) dose-dependently inhibits MPO activity in a mouse peritonitis model^[1].
Aminopyridine 2 (~50-200 mg/kg; mixed with diet for 14 days) dose-dependently inhibits MPO activity in a mouse peritonitis model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8 weeks old)^[1]
Dosage:

2.5 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:

i.g.; single dose
Result:

Reduced residual plasma MPO activity by 24% at 2.5 mg/kg, 62% at 25 mg/kg, 74% at 50 mg/kg, and 86% at 100 mg/kg, measured 5 hours post-dose.
Caused dose-dependent inhibition of 3-chlorotyrosine accumulation in peritoneal exudate.
Achieved an apparent in vivo IC₅₀ of 1.4 μM for inhibition of plasma MPO activity.

化学情報

CAS 番号 2411643-58-6
分子量 321.18
分子式 C₁₃H₁₃BrN₄O
SMILES

O=C(NC1=CC=C(Br)C=C1)NCC2=CN=C(N)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Marro ML, et al. Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor. J Pharmacol Exp Ther. 2018;367(1):147-154. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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