Anticancer agent 107
Anticancer agent 107(Compd 11jc) has significant antitumor activity and can be used as an anticancer agent in the study of pulmonary metastatic melanoma.
For research use only. We do not sell to patients.
- CAS No.: 2397573-96-3
- Formula: C24H19N3O4S
- Molecular Weight:445.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
8.8 μM
Compound: 11jc
|
Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| B16-F10 | IC50 |
6.2 μM
Compound: 11jc
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Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| CT26 | IC50 |
9.3 μM
Compound: 11jc
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Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| MEF | IC50 |
>100 μM
Compound: 11jc
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Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
Chemical Information
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CAS No. 2397573-96-3
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Molecular Weight 445.49
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Formula C24H19N3O4S
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SMILES
N#CC(C/1=O)=C(NC(C2=C3SC4=C2CCCCC4)=O)N3C1=C\C(C5=CC=C(OC)C=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 107 Related Classifications
HY-149951 Related Classifications
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