Anticancer agent 46
Based on 1 Customer Validation
Anticancer agent 46 is an anti cancer agent. Anticancer agent 46 can be used in the research of gastric cancer.
For research use only. We do not sell to patients.
- Purity: 95.73%
- CAS No.: 2426686-17-9
- Formula: C15H14ClN3OS
- Molecular Weight:319.81
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| GES1 | IC50 |
27.93 μM
Compound: 5n
|
Cytotoxicity against human GES-1 cells after 72 hrs by MTT assay
Cytotoxicity against human GES-1 cells after 72 hrs by MTT assay
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[PMID: 30108734] |
| MCF7 | IC50 |
9.99 μM
Compound: 5n
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 30108734] |
| MGC-803 | IC50 |
>64 μM
Compound: 5n
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Antiproliferative activity against human MGC803 cells after 24 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 24 hrs by MTT assay
|
[PMID: 30108734] |
| MGC-803 | IC50 |
0.93 μM
Compound: 5n
|
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
|
[PMID: 30108734] |
| MGC-803 | IC50 |
0.986 μM
Compound: 2
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Antiproliferative activity against human MGC-803 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
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[PMID: 32438199] |
| MGC-803 | IC50 |
9.22 μM
Compound: 5n
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Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
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[PMID: 30108734] |
| SMMC-7721 | IC50 |
19.18 μM
Compound: 5n
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Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
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[PMID: 30108734] |
Anticancer agent 46 (Compound 2) inhibits the proliferation of human gastric cancer MGC803 cells after 72 h, with an IC50 value of 0.986 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2426686-17-9
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Appearance Solid
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Molecular Weight 319.81
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Formula C15H14ClN3OS
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Color Light yellow to yellow
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SMILES
C/C(C1=CC(Cl)=CC=C1O)=N\NC(NC2=CC=CC=C2)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (390.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1269 mL | 15.6343 mL | 31.2686 mL | 78.1714 mL |
| 5 mM | 0.6254 mL | 3.1269 mL | 6.2537 mL | 15.6343 mL | |
| 10 mM | 0.3127 mL | 1.5634 mL | 3.1269 mL | 7.8171 mL | |
| 15 mM | 0.2085 mL | 1.0423 mL | 2.0846 mL | 5.2114 mL | |
| 20 mM | 0.1563 mL | 0.7817 mL | 1.5634 mL | 3.9086 mL | |
| 25 mM | 0.1251 mL | 0.6254 mL | 1.2507 mL | 3.1269 mL | |
| 30 mM | 0.1042 mL | 0.5211 mL | 1.0423 mL | 2.6057 mL | |
| 40 mM | 0.0782 mL | 0.3909 mL | 0.7817 mL | 1.9543 mL | |
| 50 mM | 0.0625 mL | 0.3127 mL | 0.6254 mL | 1.5634 mL | |
| 60 mM | 0.0521 mL | 0.2606 mL | 0.5211 mL | 1.3029 mL | |
| 80 mM | 0.0391 mL | 0.1954 mL | 0.3909 mL | 0.9771 mL | |
| 100 mM | 0.0313 mL | 0.1563 mL | 0.3127 mL | 0.7817 mL |
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