Antioxidant agent-17
Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC50 of 9.06 nM.
For research use only. We do not sell to patients.
- Formula: C20H15FN2O
- Molecular Weight:318.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
>10000 nM
Compound: 59
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Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate incubated for 5 mins
Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate incubated for 5 mins
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[PMID: 37918036] |
| Neutrophil | IC50 |
9.06 nM
Compound: 59
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Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation preincubated with compound for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis
Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation preincubated with compound for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis
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[PMID: 37918036] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 318.34
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Formula C20H15FN2O
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SMILES
FC1=CC=CC=C1CN2N=C(C3=CC=CO3)C=C2C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antioxidant agent-17 Related Classifications
HY-156468 Related Classifications
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