Antitubercular agent-54
Antitubercular agent-54 is an antitubercular agent with potent intramacrophage activity (EC50 = 0.68 μM). Antitubercular agent-54 shows a MIC of 0.31 μM against Mycobacterium tuberculosis (Mtb) H37Rv in cholesterol-containing medium. Antitubercular agent-54 can be used for the research of tuberculosis.
For research use only. We do not sell to patients.
- Formula: C15H19N5O2
- Molecular Weight:301.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Antitubercular agent-54 (Compound P39) exhibits potent inhibitory activity against Mtb in various metabolic states, with an EC50 of 0.68 μM against intramacrophage Mtb and an MIC of 0.31 μM against Mtb H37Rv in cholesterol-containing medium[1].
Antitubercular agent-54 (>40 μM) shows no significant cytotoxicity against HEK293T and HepG2 cells, with good safety profiles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Note | Cmax | Tmax | MRT0-last | AUC0-last |
|---|---|---|---|---|---|---|---|
| Mice | 20 mg/kg | p.o. | 文献审核 | 8533 ng/mL | 8.0 h | 7.23 h | 58754 ng·h/mL |
Chemical Information
-
Molecular Weight 301.34
-
Formula C15H19N5O2
-
SMILES
O=C(N)CN1N=C(C2=CC=C(OCC(C3CC3)C)C=C2)N=N1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitubercular agent-54 Related Classifications
HY-179673 Related Classifications
Powered by Bioz