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Art. -Nr.: HY-179638

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Antiviral agent 74

Antiviral agent 74 is an antiviral agent consisting of Cidofovir (HY-17438) prodrug and lipid chain. Antiviral agent 74 can inhibit the activity of viral DNA polymerase by transforming into Cidofovir.Antiviral agent 74 demonstrates potent antiviral activity against vacciniavirus (VACV) (EC₅₀ = 0.156 μM) comparable to Brincidofovir (HY-14532). Antiviral agent 74 shows superior potency against monkeypox virus (MPXV) with an EC₅₀ vales of 0.202 μM. Antiviral agent 74 can be used for the research of virus infection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3059641-72-1
Formel: C₂₈H₅₄N₃O₈PS
Molecular Weight:623.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

Antiviral agent 74 Chemical Structure

CAS. Nr.: 3059641-72-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Antiviral agent 74 (Compound 13f) demonstrates potent antiviral activity against vacciniavirus (VACV) and monkeypox virus (MPXV) in Vero cells with EC₅₀ values of 0.156 and 0.202 μM and^[1].
Antiviral agent 74 demonstrates low cytotoxicity in Vero cells with a CC₅₀ of 11.36 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_last	F	T_1/2
Rat	3 mg/kg	i.v.	5.63.5 ng/mL	/	1873.9 ng·h/mL	/	0.19 h
Rat	15 mg/kg	p.o.	668.4 ng/mL	0.83 h	1607.4 ng·h/mL	17.16 %	1.89 h

Chemical Information

CAS. Nr. 3059641-72-1
Molecular Weight 623.78
Formel C₂₈H₅₄N₃O₈PS
SMILES

OP(OCCS(CCCCCCCCCCCCCCCCCC)(=O)=O)(CO[C@H](CO)CN1C=CC(N)=NC1=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang B, et al. Lipid-Optimized Sulfone-Bridged Cidofovir Prodrugs as Potent Antivirals Against Orthopoxviruses. J Med Chem. 2025;68(22):23867-23885. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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Antiviral agent 74

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