2. Anti-infection Cell Cycle/DNA Damage
  3. Orthopoxvirus DNA/RNA Synthesis
  4. Antiviral agent 74

Antiviral agent 74 is an antiviral agent consisting of Cidofovir (HY-17438) prodrug and lipid chain. Antiviral agent 74 can inhibit the activity of viral DNA polymerase by transforming into Cidofovir.Antiviral agent 74 demonstrates potent antiviral activity against vacciniavirus (VACV) (EC50 = 0.156 μM) comparable to Brincidofovir (HY-14532). Antiviral agent 74 shows superior potency against monkeypox virus (MPXV) with an EC50 vales of 0.202 μM. Antiviral agent 74 can be used for the research of virus infection.

For research use only. We do not sell to patients.

Antiviral agent 74

Antiviral agent 74 Chemical Structure

CAS No. : 3059641-72-1

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Antiviral agent 74 Related Antibodies

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Description

Antiviral agent 74 is an antiviral agent consisting of Cidofovir (HY-17438) prodrug and lipid chain. Antiviral agent 74 can inhibit the activity of viral DNA polymerase by transforming into Cidofovir.Antiviral agent 74 demonstrates potent antiviral activity against vacciniavirus (VACV) (EC50 = 0.156 μM) comparable to Brincidofovir (HY-14532). Antiviral agent 74 shows superior potency against monkeypox virus (MPXV) with an EC50 vales of 0.202 μM. Antiviral agent 74 can be used for the research of virus infection[1].

In Vitro

Antiviral agent 74 (Compound 13f) demonstrates potent antiviral activity against vacciniavirus (VACV) and monkeypox virus (MPXV) in Vero cells with EC50 values of 0.156 and 0.202 μM and[1].
Antiviral agent 74 demonstrates low cytotoxicity in Vero cells with a CC50 of 11.36 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiviral agent 74 Related Antibodies
Parmacokinetics
Species Dose Route Cmax Tmax AUClast F T1/2
Rat 3 mg/kg i.v. 5.63.5 ng/mL / 1873.9 ng·h/mL / 0.19 h
Rat 15 mg/kg p.o. 668.4 ng/mL 0.83 h 1607.4 ng·h/mL 17.16 % 1.89 h
Molecular Weight

623.78

Formula

C28H54N3O8PS
CAS No.
SMILES

OP(OCCS(CCCCCCCCCCCCCCCCCC)(=O)=O)(CO[C@H](CO)CN1C=CC(N)=NC1=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Antiviral agent 74 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiviral agent 743059641-72-1Antiviral agent74Antiviral agent-74OrthopoxvirusDNA/RNA SynthesisVeroVACVMPXVInhibitorinhibitorinhibit

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