1. Apoptosis
  2. Apoptosis
  3. Apoptosis inducer 4

Apoptosis inducer 4 

Cat. No.: HY-146092
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Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities.

For research use only. We do not sell to patients.

Apoptosis inducer 4 Chemical Structure

Apoptosis inducer 4 Chemical Structure

CAS No. : 2408050-83-7

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Description

Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities[1].

In Vitro

Apoptosis inducer 4 (Compound 12b) (0-50 µM, 72 h) shows antiproliferative activities against cancer cells without obvious cytotoxicity against normal cells[1].
Apoptosis inducer 4 (0-2 µM, 48 h) causes cell cycle arrest at S phase in K562 cells and G1 phase in HepG2 cells[1].
Apoptosis inducer 4 (0-4 µM, 24 and 48 h) induces pyknosis in K562 cells, and induces mitochondrial membrane potentials decline[1].
Apoptosis inducer 4 (0-2 µM, 72 h) induces apoptosis in K562 and HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Showed antiproliferative activities with IC50 values of 2.57 ± 0.12, 16.15 ± 1.02, 5.81 ± 1.17, 12.94 ± 0.88, 0.95 ± 0.06, 17.59 ± 0.93 and >50 µM against HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC cells, respectively.

Cell Cycle Analysis[1]

Cell Line: K562 and HepG2 cells
Concentration: K562 and HepG2 cells
Incubation Time: 48 h
Result: Arrested K562 cell cycle at S phase and HepG2 cell at G1 phase.

Apoptosis Analysis[1]

Cell Line: K562 and HepG2 cells
Concentration: K562 and HepG2 cells
Incubation Time: 72 h
Result: Apoptotic ratios of K562 and HepG2 cells obviously increased in a concentration-dependent manner.
Molecular Weight

815.02

Formula

C41H50O11S3

CAS No.
SMILES

O[[email protected]]12[[email protected]]34[[email protected]](CC[[email protected]@H](C(C4=O)=C)[[email protected]]3OC(CCC(OCCCCCCOC5=CC=C(C(SS6)=CC6=S)C=C5)=O)=O)([H])[[email protected]@]7(CO2)[[email protected]](C(C)(CC[[email protected]@H]7OC(C)=O)C)([H])[[email protected]@H]1O

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Apoptosis inducer 4
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