Apoptosis inducer 4
Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities.
For research use only. We do not sell to patients.
- CAS No.: 2408050-83-7
- Formula: C41H50O11S3
- Molecular Weight:815.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Apoptosis inducer 4 (Compound 12b) (0-50 µM, 72 h) shows antiproliferative activities against cancer cells without obvious cytotoxicity against normal cells[1].
Apoptosis inducer 4 (0-2 µM, 48 h) causes cell cycle arrest at S phase in K562 cells and G1 phase in HepG2 cells[1].
Apoptosis inducer 4 (0-4 µM, 24 and 48 h) induces pyknosis in K562 cells, and induces mitochondrial membrane potentials decline[1].
Apoptosis inducer 4 (0-2 µM, 72 h) induces apoptosis in K562 and HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC
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Concentration:0-50 µM
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Incubation Time:72 h
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Result:Showed antiproliferative activities with IC50 values of 2.57 ± 0.12, 16.15 ± 1.02, 5.81 ± 1.17, 12.94 ± 0.88, 0.95 ± 0.06, 17.59 ± 0.93 and >50 µM against HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC cells, respectively.
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Cell Line:K562 and HepG2 cells
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Concentration:K562 and HepG2 cells
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Incubation Time:48 h
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Result:Arrested K562 cell cycle at S phase and HepG2 cell at G1 phase.
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Cell Line:K562 and HepG2 cells
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Concentration:K562 and HepG2 cells
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Incubation Time:72 h
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Result:Apoptotic ratios of K562 and HepG2 cells obviously increased in a concentration-dependent manner.
Chemical Information
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CAS No. 2408050-83-7
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Molecular Weight 815.02
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Formula C41H50O11S3
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SMILES
O[C@]12[C@]34[C@](CC[C@@H](C(C4=O)=C)[C@H]3OC(CCC(OCCCCCCOC5=CC=C(C(SS6)=CC6=S)C=C5)=O)=O)([H])[C@@]7(CO2)[C@](C(C)(CC[C@@H]7OC(C)=O)C)([H])[C@@H]1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 4 Related Classifications
HY-146092 Related Classifications
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