1. Anti-infection
  2. HCV
    SARS-CoV
  3. AT-511

AT-511 

Cat. No.: HY-137958A
Handling Instructions

AT-511 is a potent and orally active HCV viral replication inhibitor. AT-511 is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). AT-511 has pangenotypic antiviral activity.

For research use only. We do not sell to patients.

AT-511 Chemical Structure

AT-511 Chemical Structure

CAS No. : 1998705-64-8

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5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AT-511 is a potent and orally active HCV viral replication inhibitor. AT-511 is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). AT-511 has pangenotypic antiviral activity[1][2][3].

IC50 & Target

EC50: 5-28 nM (HCV)[1]
EC90: 0.47 μM (SARS-CoV-2)[2]

In Vitro

AT-511 has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively[1].
In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), AT-527 preferentially delivers high levels of AT-9010 in the liver in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

581.53

Formula

C₂₄H₃₃FN₇O₇P

CAS No.
SMILES

C[[email protected]@]1([[email protected]](O[[email protected]@H]([[email protected]]1O)COP(OC2=CC=CC=C2)(N[[email protected]@H](C)C(OC(C)C)=O)=O)([H])N3C4=NC(N)=NC(NC)=C4N=C3)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Keywords:

AT-511AT511AT 511HCVSARS-CoVHepatitis C virusSARS coronavirusphosphoramidateguanosinenucleotideSARS-CoV-2pangenotypicantiviralInhibitorinhibitorinhibit

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AT-511
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