1. Anti-infection
  2. HCV
    SARS-CoV
  3. AT-527

AT-527 

Cat. No.: HY-137958
Handling Instructions

AT-527, a hemisulfate salt of AT-511, a guanosine nucleotide prodrug, is a potent and orally active HCV viral replication inhibitor. AT-527 is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). AT-527 has pangenotypic antiviral activity.

For research use only. We do not sell to patients.

AT-527 Chemical Structure

AT-527 Chemical Structure

CAS No. : 2241337-84-6

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Description

AT-527, a hemisulfate salt of AT-511, a guanosine nucleotide prodrug, is a potent and orally active HCV viral replication inhibitor. AT-527 is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). AT-527 has pangenotypic antiviral activity[1][2][3].

IC50 & Target

EC50: 5-28 nM (HCV)[1]
EC90: 0.47 μM (SARS-CoV-2)[2]

In Vitro

AT-511 has pan-genotypic antiviral activities that inhibits HCV genotype 1a (HCV GT1a), HCV GT1b, HCV GT2a, HCV GT3a, HCV GT4a, and HCV GT5a replication with EC50 values of 12.8 nM, 12.5 nM, 9.2 nM, 10.3 nM, 14.7 nM, and 28.5 nM, respectively[1].
In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), AT-527 preferentially delivers high levels of AT-9010 in the liver in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

630.58

Formula

C₂₄H₃₃FN₇O₇P.₁/₂H₂O₄S

CAS No.

2241337-84-6

SMILES

C[[email protected]]([[email protected]](O[[email protected]@H]1CO[[email protected]](OC2=CC=CC=C2)(N[[email protected]@H](C)C(OC(C)C)=O)=O)([H])N3C4=NC(N)=NC(NC)=C4N=C3)([[email protected]@H]1O)F.OS(O)(=O)=O.[1/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AT-527AT527AT 527HCVSARS-CoVHepatitis C virusSARS coronavirusphosphoramidateguanosinenucleotideSARS-CoV-2pangenotypicantiviralInhibitorinhibitorinhibit

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AT-527
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