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Art. -Nr.: HY-28911

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2-Hydroxyacetaldehyde

2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways.

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CAS. Nr.: 141-46-8
Formel: C₂H₄O₂
Molecular Weight:60.05

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Hydroxyacetaldehyde Chemical Structure

CAS. Nr.: 141-46-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

In Vitro

2-Hydroxyacetaldehyde (80 mM; 2.5-21 h at 37°C) rapidly modifies lysine residues on human LDL^[1].
2-hydroxyacetaldehyde-modified human LDL (100 μg/mL) does not compete with native LDL for LDL receptors on cultured normal human fibroblasts, resulting in a degradation rate of 94% relative to the no-competitor control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 141-46-8
Molecular Weight 60.05
Formel C₂H₄O₂
SMILES

OCC=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Shepherd J, Packard C J. Receptor-independent low-density lipoprotein catabolism[M]//Methods in enzymology. Academic Press, 1986, 129: 566-590.

[2]. Harman CE, et al. Atmospheric production of glycolaldehyde under hazy prebiotic conditions. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 2013 Apr;43(2):77-98. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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