3'-Deoxy-GTP
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate), an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP inhibits DENV NS5 RdRp (IC50: 0.02 μM).
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- CAS. Nr.: 55968-37-1
- Formel: C10H16N5O13P3
- Molecular Weight:507.18
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 55968-37-1
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Molecular Weight 507.18
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Formel C10H16N5O13P3
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SMILES
O=C1C2=C(N([C@H]3[C@H](O)C[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3)C=N2)NC(N)=N1
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Synonyms
3′-Deoxyguanosine 5′-triphosphate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
[1]. Yin Z, et al. An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20435-9. [Content Brief]
[2]. Oliveira AF, et al. Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses. Molecules. 2017 Mar 22;22(3):505. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
3'-Deoxy-GTP Related Classifications
HY-134991 Related Classifications
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