5J-4
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation.
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- Reinheit : 95%
- CAS. Nr.: 827001-82-1
- Formel: C16H12N2O3S
- Molecular Weight:312.35
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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HY-N1370
Tanshinone IIA sulfonate sodiumSOCE Inhibitor -
HY-101942
ZegocractinSOCE Inhibitor -
HY-111325
Synta66CRAC Channel Inhibitor -
HY-113618B
RO2959 monohydrochlorideCRAC Channel Inhibitor -
HY-12521
GSK-5498ACARC Inhibitor -
HY-20588
CRAC intermediate 2CRAC Inhibitor Synthesis Intermediate -
HY-113618A
RO2959 hydrochloride -
HY-20587
CRAC intermediate 1Synthetic Intermediate -
HY-147005
piCRAC-1CRAC Channel Inhibitor -
HY-101942R
Zegocractin (Standard)Reference Standard -
HY-N1370R
Tanshinone IIA sulfonate sodium (Standard)SOCE Inhibitor
Biologische Aktivität
Beschreibung
In Vivo
5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)[1]
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Dosage:2 m/kg
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Administration:I.p., every alternate day for 30 days
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Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.
Chemical Information
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CAS. Nr. 827001-82-1
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Appearance Powder
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Molecular Weight 312.35
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Formel C16H12N2O3S
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Color White to off-white
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SMILES
O=C(C1=CC=CO1)NC(NC2=CC=CC3=C2C=CC(O)=C3)=S
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
5J-4 Related Classifications
HY-110216 Related Classifications
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