Art. -Nr.: HY-W011689

6PPD

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Based on 1 publication(s) in Google Scholar

6PPD is a rubber antioxidant that scavenges ozone and forms nitro radicals. Exposure to 6PPD reduces the hatching rate, impairs spontaneous locomotor activity, shortens body length and causes malformations in zebrafish embryos. 6PPD also induces oxidative stress in zebrafish embryos.

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Reinheit: 98.46%
CAS. Nr.: 793-24-8
Formel: C₁₈H₂₄N₂
Molecular Weight:268.40

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

6PPD Chemical Structure

CAS. Nr.: 793-24-8

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Publications Citing Use of MedChemExpress (MCE) 6PPD

Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]

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Cell Imaging/StainingCell Proliferation/Viability AssayWBBio/Physico-chemical Assay

Cell Imaging/Staining
Cell Proliferation/Viability Assay
WB
Bio/Physico-chemical Assay
Bio/Physico-chemical Assay

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

6PPD (0.0022-5 mg/L; aqueous exposure; daily renewal; 96-120 hours) causes concentration-dependent developmental toxicity, GH/IGF and HPT axis disruption, and oxidative stress in Danio rerio embryos/larvae, with a 96 h LC₅₀ of 2.2 mg/L and significant developmental impairment and endocrine disruption observed at doses as low as 0.0022 mg/L^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

wild-type AB strain (2 hours post-fertilization embryos)^[1]
Dosage:

0.0022 mg/L; 0.022 mg/L; 0.22 mg/L; 0.3125 mg/L; 0.625 mg/L; 1.25 mg/L; 2.5 mg/L; 5 mg/L
Administration:

aqueous exposure; daily renewal; 96 hours (0.3125-5 mg/L); 120 hours (0.0022-0.22 mg/L)
Result:

Determined the 96 h LC₅₀of 6PPD for zebrafish embryos as 2.2 mg/L .
Reduced hatchability by 25.6% (0.022 mg/L) and 78.9% (0.22 mg/L) relative to controls.
Reduced autonomous movement (60-second count at 96 hours) by 19.9% (0.022 mg/L) and 56.25% (0.22 mg/L) relative to controls.

Chemical Information

CAS. Nr. 793-24-8
Appearance Solid
Molecular Weight 268.40
Formel C₁₈H₂₄N₂
Color Brown to gray
SMILES

CC(C)CC(NC1=CC=C(NC2=CC=CC=C2)C=C1)C
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All Cell Imaging/StainingCell Proliferation/Viability AssayWBBio/Physico-chemical Assay

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Ecotoxicol Environ Saf

Human cardiac organoids highlight cardiotoxicity of the tire rubber antioxidant 6PPD. [Abstract]

2025 Dec 1:308:119496. PMID: 41330299

6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]

6PPD (0.1-100 μM) exposure led to a concentration-dependent increase in dead cells, accompanied by a corresponding reduction in the live tissue area.

6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]

The calculated IC₅₀ of 6PPD was approximately 56.9 μM, with substantial cytotoxicity occurring only at concentrations above this threshold.

6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]

Significant changes in apoptotic markers were observed only at 100 μM 6PPD.

6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]

Acute electrophysiological responses were assessed by continuous MEA recording for 60 min following 6PPD treatment, with measurements taken at 10-min intervals.

6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]

The beat rate (beats per minute, BPM) increased over 60 min at 10 μM 6PPD.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (745.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7258 mL

18.6289 mL

37.2578 mL

5 mM

0.7452 mL

3.7258 mL

7.4516 mL

10 mM

0.3726 mL

1.8629 mL

3.7258 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Peng W, et al. Exposure to N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) affects the growth and development of zebrafish embryos/larvae. Ecotoxicol Environ Saf. 2022;232:113221. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7258 mL	18.6289 mL	37.2578 mL	93.1446 mL
	5 mM	0.7452 mL	3.7258 mL	7.4516 mL	18.6289 mL
	10 mM	0.3726 mL	1.8629 mL	3.7258 mL	9.3145 mL
	15 mM	0.2484 mL	1.2419 mL	2.4839 mL	6.2096 mL
	20 mM	0.1863 mL	0.9314 mL	1.8629 mL	4.6572 mL
	25 mM	0.1490 mL	0.7452 mL	1.4903 mL	3.7258 mL
	30 mM	0.1242 mL	0.6210 mL	1.2419 mL	3.1048 mL
	40 mM	0.0931 mL	0.4657 mL	0.9314 mL	2.3286 mL
	50 mM	0.0745 mL	0.3726 mL	0.7452 mL	1.8629 mL
	60 mM	0.0621 mL	0.3105 mL	0.6210 mL	1.5524 mL
	80 mM	0.0466 mL	0.2329 mL	0.4657 mL	1.1643 mL
	100 mM	0.0373 mL	0.1863 mL	0.3726 mL	0.9314 mL

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6PPD

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Human Metabolite Library

Radioprotector Library

Bioactive Compound Library Max

Bioactive Compound Library

Anti-Fibrosis Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) 6PPD

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

6PPD

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Oxygen Sensing Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Human Metabolite Library

Radioprotector Library

Bioactive Compound Library Max

Bioactive Compound Library

Anti-Fibrosis Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) 6PPD

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

6PPD Related Classifications

HY-W011689 Related Classifications