Men 10376
Based on 1 publication(s) in Google Scholar
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
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- CAS. Nr.: 135306-85-3
- Formel: C57H68N12O10
- Molecular Weight:1081.22
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Men 10376
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Biologische Aktivität
Ki: 4.4 μM (NK-2 receptor, rat small intestine)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
78.1 nM
Compound: MEN-10376
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Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
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[PMID: 16562853] |
Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 135306-85-3
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Molecular Weight 1081.22
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Formel C57H68N12O10
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Synonyms
Neurokinin-2 receptor antagonist
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Sequence
Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2
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Sequence Shortening
DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Reinheit & Dokumentation
Verweise
[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36. [Content Brief]
[2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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