Art. -Nr.: HY-111534

SBI-115

39 Cited Publications

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Based on 39 publication(s) in Google Scholar

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.

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Reinheit: 99.58%
CAS. Nr.: 882366-16-7
Formel: C₁₄H₁₃ClN₂O₄S
Molecular Weight:340.78

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SBI-115 Chemical Structure

CAS. Nr.: 882366-16-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (39)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5^[1].

In Vitro

SBI-115 (100-200 μM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

shRNA-transfected ADPKD cholangiocytes
Concentration:

100, 200 µM
Incubation Time:

24 hours
Result:

Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA.

Chemical Information

CAS. Nr. 882366-16-7
Appearance Solid
Molecular Weight 340.78
Formel C₁₄H₁₃ClN₂O₄S
Color White to off-white
SMILES

O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)OC2=CC=CC(C)=C2
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (39)

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Journal Impact Factor

Cell Metab

Gut microbiota-derived deoxycholic acid shapes an immunosuppressive tumor microenvironment and promotes breast cancer progression. [Abstract]

2026 May 12:S1550-4131(26)00149-X. PMID: 42127890
Nat Commun

The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice. [Abstract]

2022 Oct 14;13(1):6081. PMID: 36241632

SBI-115 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Oct 14;13(1):6081. [Abstract]

SBI-115 (10 μM, 48 h) inhibited 1,5-AG-induced expression of collagen I and vimentin in primary mouse renal tubular epithelial cells.
Acta Pharm Sin B

TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization. [Abstract]

2022 Feb;12(2):787-800. PMID: 35256947

SBI-115 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):787-800. [Abstract]

SBI-115 (10 μM, 48 h) decreased the upregulation of M2 markers, accompanied by increased expression of the M1 marker, in BMDMs that were cultured with CM collected from LLC cell culture.

SBI-115 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):787-800. [Abstract]

SBI-115 (5 or 10 μM, 48 h) resulted in increased tumor phagocytic capacity of CM-treated BMDMs.

SBI-115 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):787-800. [Abstract]

SBI-115 (5 or 10 μM, 48 h) inhibited CM-macrophage-induced Lewis lung carcinoma cell migration and invasion.

SBI-115 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):787-800. [Abstract]

SBI-115 (5 or 10 μM, 48 h) increased the percentage of granzyme B⁺ cells among CD8b⁺ T cells co-cultured with Lewis lung carcinoma CM-educated BMDMs.
J Adv Res

A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization. [Abstract]

2025 Apr 22:S2090-1232(25)00278-4. PMID: 40274226
Microbiome

Gut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets. [Abstract]

2024 Feb 5;12(1):20. PMID: 38317217
Pharmacol Res

Lactobacillus rhamnosus GG ameliorates triptolide-induced liver injury through modulation of the bile acid-FXR axis. [Abstract]

2024 Jun 20:107275. PMID: 38908615
Pharmacol Res

GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients. [Abstract]

2022 Oct:184:106459. PMID: 36152741
NPJ Biofilms Microbiomes

Parabacteroides goldsteinii and its metabolite 7-KLCA attenuate endometriosis via TGR5 to reprogram macrophages by modulating the PPARγ/GPR132 axis. [Abstract]

2026 May 22. PMID: 42173876
NPJ Biofilms Microbiomes

Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-κB/NLRP3 pathways in mice. [Abstract]

2023 Feb 8;9(1):8. PMID: 36755021
Int J Biol Macromol

Salidroside attenuates NASH through regulating bile acid-FXR/TGR5 signaling pathway via targeting gut microbiota. [Abstract]

2025 Mar 19:142276. PMID: 40118401
Phytomedicine

Huodan Qinghua formula inhibits CD36 membrane localisation via the TGR5-DHHC4 pathway to ameliorate lipotoxic damage in diabetic cardiomyopathy. [Abstract]

2026 Jan 1:153:157761. PMID: 41678909
Phytomedicine

Yi-Fei-San-Jie Chinese medicine formula reverses immune escape by regulating deoxycholic acid metabolism to inhibit TGR5/STAT3/PD-L1 axis in lung cancer. [Abstract]

2024 Oct 29:135:156175. PMID: 39515098
Phytomedicine

Red ginseng extracts ameliorate high-fat diet-induced obesity and insulin resistance by activating the intestinal TGR5-mediated bile acids signaling pathway. [Abstract]

2023 Oct:119:154982. PMID: 37531904
Food Science and Human Wellness

2023 Nov;12(6);2061-2072.
Cell Rep

Gut Bacteroides ovatus ameliorates renal fibrosis by promoting the production of HDCA through upregulation of Clostridium scindens. [Abstract]

2024 Oct 10;43(10):114830. PMID: 39392759
J Anim Sci Biotechnol

Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows. [Abstract]

2025 Oct 30;16(1):142. PMID: 41163235
Mol Med

Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro. [Abstract]

2025 Jan 29;31(1):31. PMID: 39881219
J Agric Food Chem

Synbiotic Intervention with Inulin and Lactiplantibacillus plantarum LPm77 Attenuates Type 2 Diabetes via Enhanced TUDCA Metabolism and Gut-Liver Axis Modulation. [Abstract]

2025 Aug 6;73(31):19442-19459. PMID: 40708558
J Agric Food Chem

Probiotic Combination of Limosilactobacillus fermentum HF07 and Lactococcus lactis HF08 Targeting Gut Microbiota-Secondary Bile Acid Metabolism Ameliorates Inflammation and Intestinal Barrier Dysfunction in Aging Colitis. [Abstract]

2025 Jun 4;73(22):13439-13454. PMID: 40391947
Acta Physiol

Activation of TGR5 Alleviates Renal Fibrosis by Promoting NEDD4L-Mediated p-Smad2/3 Ubiquitination. [Abstract]

2026 Feb;242(2):e70163. PMID: 41536162
Food Funct

Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus. [Abstract]

2024 May 7;15(9):5088-5102. PMID: 38666497
Nutrients

Bifidobacterium pseudocatenulatum-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut-Joint Axis. [Abstract]

2023 Jan 4;15(2):255. PMID: 36678126
J Nutr Biochem

Oleanolic acid inhibits appetite through the TGR5/cAMP signaling pathway. [Abstract]

2025 Jan 20:109844. PMID: 39842616
J Nutr Biochem

Oleanolic acid promotes skeletal muscle fiber type transformation by activating TGR5-mediated CaN signaling pathway. [Abstract]

2024 Jan:123:109507. PMID: 37890712
Biomolecules

Significant Reduction of Chenodeoxycholic Acid and Glycochenodeoxycholic Acid in the Elderly with Severe COVID-19. [Abstract]

2025 Jun 28;15(7):943. PMID: 40723815
Int Immunopharmacol

Taurodeoxycholic acid alleviates intestinal inflammation by modulating gut microbiota and TGR5-NF-kappaB axis in DSS-induced colitis. [Abstract]

2025 Dec 24:170:116056. PMID: 41448004
Int Immunopharmacol

Targeting TGR5 to mitigate liver fibrosis: Inhibition of hepatic stellate cell activation through modulation of mitochondrial fission. [Abstract]

2024 Aug 6:140:112831. PMID: 39111149
iScience

Microbiome-encoded bile acid metabolism modulates colonic transit times. [Abstract]

2021 May 5;24(6):102508. PMID: 34142026
Cell Signal

Membrane receptor TGR5 upregulates IP3R-induced calcium overload: Key mechanism of bile acid-induced acute pancreatitis. [Abstract]

2026 Aug:144:112512. PMID: 41921768
Aquacult Rep

February 2022, 100997.
Microb Pathog

Lithocholic acid exerts antiviral activity against porcine epidemic diarrhea virus by enhancing TGR5-mediated type III interferon production. [Abstract]

2026 Jan:210:108187. PMID: 41242567
Discov Oncol

Investigation of the potential role of TGR5 in pancreatic cancer by a comprehensive molecular experiments and the liquid chromatography mass spectrometry (LC-MS) based metabolomics. [Abstract]

2022 Jun 11;13(1):46. PMID: 35689739
Front Neurol

Smooth muscle contractile responses to bile acids in mouse ileum require TGR5 but not ASBT. [Abstract]

2024 Apr 24:15:1334319. PMID: 38721114
Biochem Biophys Res Commun

Python-derived 16α-Hydroxylated Bile Acid, Pythocholic Acid is a ligand for TGR5, not farnesoid X receptors and vitamin D receptors. [Abstract]

2025 Feb 4:751:151453. PMID: 39923459
Transl Pediatr

Chenodeoxycholic acid activates the TGR5/TRPA1-5-HT pathway to regulate intestinal motility in breastfed infants and mouse models. [Abstract]

2025 Jun 27;14(6):1213-1229. PMID: 40688229
STAR Protoc

Marker-based assays for studying gut transit in gnotobiotic and conventional mouse models. [Abstract]

2021 Nov 5;2(4):100938. PMID: 34806048
bioRxiv

A microbiota-derived bile acid overcomes antibiotic-induced hyporesponsiveness to immune checkpoint therapy by enhancing CD8 + T cell antitumor immunity. [Abstract]

2026 Apr 19:2026.04.15.718788. PMID: 42039389
bioRxiv

2025 Nov 8.
Universidad de Córdoba

2025.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (293.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9344 mL

14.6722 mL

29.3444 mL

5 mM

0.5869 mL

2.9344 mL

5.8689 mL

10 mM

0.2934 mL

1.4672 mL

2.9344 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 2% DMSO 40% PEG300 5% Tween-80 53% Saline

Solubility: 3 mg/mL (8.80 mM); Suspended solution; Need ultrasonic

Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Corn Oil

Solubility: 5 mg/mL (14.67 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Masyuk TV, et al. TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct; 66(4):1197-1218. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9344 mL	14.6722 mL	29.3444 mL	73.3611 mL
	5 mM	0.5869 mL	2.9344 mL	5.8689 mL	14.6722 mL
	10 mM	0.2934 mL	1.4672 mL	2.9344 mL	7.3361 mL
	15 mM	0.1956 mL	0.9781 mL	1.9563 mL	4.8907 mL
	20 mM	0.1467 mL	0.7336 mL	1.4672 mL	3.6681 mL
	25 mM	0.1174 mL	0.5869 mL	1.1738 mL	2.9344 mL
	30 mM	0.0978 mL	0.4891 mL	0.9781 mL	2.4454 mL
	40 mM	0.0734 mL	0.3668 mL	0.7336 mL	1.8340 mL
	50 mM	0.0587 mL	0.2934 mL	0.5869 mL	1.4672 mL
	60 mM	0.0489 mL	0.2445 mL	0.4891 mL	1.2227 mL
	80 mM	0.0367 mL	0.1834 mL	0.3668 mL	0.9170 mL
	100 mM	0.0293 mL	0.1467 mL	0.2934 mL	0.7336 mL

Keywords

SBI-115

39 Cited Publications

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SBI-115

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Covalent Screening Library

Anti-Obesity Compound Library

Lipid Metabolism Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) SBI-115

Biologische Aktivität

Chemical Information

Publications (39)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SBI-115

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Covalent Screening Library

Anti-Obesity Compound Library

Lipid Metabolism Compound Library

Heterocyclic Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) SBI-115

Biologische Aktivität

Chemical Information

Publications (39)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

SBI-115 Related Classifications

HY-111534 Related Classifications