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Art. -Nr.: HY-W1142089

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ActRIIB-IN-2

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC₅₀ of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3039974-32-5
Formel: C₂₆H₂₅N₅
Molecular Weight:407.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-2 Chemical Structure

CAS. Nr.: 3039974-32-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC₅₀ of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia^[1].

IC₅₀ & Target

^[1]

ACVR2B

1.1 nM (IC₅₀)

Alle TGF-β Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

ActRIIB-IN-2 (2.5 μM; 48 h) achieved a 90.87% reversal rate in myotube atrophy^[1].
ActRIIB-IN-2 (Compound 3) potently inhibits ActRIIB in a cell-free biochemical assay with an IC₅₀ of 1.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ActRIIB-IN-2 (10 mg/kg; daily for 16 days) alleviates weight loss, muscle atrophy, and muscle strength in BABL/c mice inoculated with CT26 cells without affecting tumor size, and slightly improves appetite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (inoculated with 1 million C26 cells in each axilla to establish a colon cancer model)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; daily for 16 days
Result:

Alleviated weight loss to some extent.
Reduced tumor volume, but not significantly.
Improved appetite.
Significantly enhanced muscle grip strength.
Improved skeletal muscle atrophy to some extent.
Significantly alleviated the reduction in the cross-sectional area of the gastrocnemius muscle.

Chemical Information

CAS. Nr. 3039974-32-5
Molecular Weight 407.51
Formel C₂₆H₂₅N₅
SMILES

CN(CC1)CCN1C(C=C2)=CC=C2C3=CC4=C(NC=C4C5=CC6=C(NC=C6)C=C5)N=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dong XC, et al. 7-azaindole compounds, preparation method therefor, and use thereof. China, WO2024114661 A. 2024-06-06.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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