country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-119951

Copy Link Print Information

AKI-001

AKI-001 is an prototype pentacyclic inhibitor of aurora kinase with cellular potency of IC₅₀ of less than 100 nM. AKI-001 shows low nanomolar potency against Aurora A and Aurora B enzymes.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 925218-37-7
Formel: C₂₁H₂₄N₄O
Molecular Weight:348.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

AKI-001 Chemical Structure

CAS. Nr.: 925218-37-7

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Aurora Kinase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.07 μM Compound: 32, AKI-001	Antiproliferative activity against human HCT116 cells Antiproliferative activity against human HCT116 cells	[PMID: 18630890]
HT-29	IC₅₀	0.07 μM Compound: 32, AKI-001	Antiproliferative activity against human HT29 cells Antiproliferative activity against human HT29 cells	[PMID: 18630890]
MCF7	IC₅₀	0.1 μM Compound: 32, AKI-001	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 18630890]
MOLT-4	IC₅₀	0.11 μM Compound: 32, AKI-001	Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs	[PMID: 18630890]

Chemical Information

CAS. Nr. 925218-37-7
Molecular Weight 348.44
Formel C₂₁H₂₄N₄O
SMILES

O=C1C(C)(C)C2=CC3=C(C=C2N1CC)C(CCCC4=C(C)NN=C45)=C5N3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Rawson, T. E., et al., (2008). A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. Journal of medicinal chemistry, 51(15), 4465-4475. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

AKI-001

Alle Aurora Kinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AKI-001 Related Classifications

HY-119951 Related Classifications