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Art. -Nr.: HY-145374

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AL-611

Kundenbewertung

Based on 1 Customer Validation

AL-611 is an HCV NS5B polymerase inhibitor (EC₅₀ = 5 nM).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.93%
CAS. Nr.: 2481279-61-0
Formel: C₂₅H₃₃F₂N₆O₈P
Molecular Weight:614.54

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

AL-611 Chemical Structure

CAS. Nr.: 2481279-61-0

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Menge

Amount: USD 0.00

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

AL-611 is an HCV NS5B polymerase inhibitor (EC₅₀ = 5 nM).

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HeLa	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HepG2	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay	[PMID: 32816483]
MT4	CC₅₀	92 μM Compound: 40	Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
U-937	CC₅₀	10 μM Compound: 40	Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 2481279-61-0
Appearance Solid
Molecular Weight 614.54
Formel C₂₅H₃₃F₂N₆O₈P
Color White to off-white
SMILES

C[C@@]1([C@](O[C@@](F)([C@H]1O)CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)([H])N3C4=NC(N)=NC(OCC)=C4N=C3)F
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (203.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6272 mL

8.1362 mL

16.2723 mL

5 mM

0.3254 mL

1.6272 mL

3.2545 mL

10 mM

0.1627 mL

0.8136 mL

1.6272 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang G, et al. Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C. J Med Chem. 2020 Sep 24;63(18):10380-10395. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6272 mL	8.1362 mL	16.2723 mL	40.6808 mL
	5 mM	0.3254 mL	1.6272 mL	3.2545 mL	8.1362 mL
	10 mM	0.1627 mL	0.8136 mL	1.6272 mL	4.0681 mL
	15 mM	0.1085 mL	0.5424 mL	1.0848 mL	2.7121 mL
	20 mM	0.0814 mL	0.4068 mL	0.8136 mL	2.0340 mL
	25 mM	0.0651 mL	0.3254 mL	0.6509 mL	1.6272 mL
	30 mM	0.0542 mL	0.2712 mL	0.5424 mL	1.3560 mL
	40 mM	0.0407 mL	0.2034 mL	0.4068 mL	1.0170 mL
	50 mM	0.0325 mL	0.1627 mL	0.3254 mL	0.8136 mL
	60 mM	0.0271 mL	0.1356 mL	0.2712 mL	0.6780 mL
	80 mM	0.0203 mL	0.1017 mL	0.2034 mL	0.5085 mL
	100 mM	0.0163 mL	0.0814 mL	0.1627 mL	0.4068 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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AL-611

MCE Bioactive Compound Library

Clinical Compound Library Plus

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

AL-611

MCE Bioactive Compound Library

Clinical Compound Library Plus

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

AL-611 Related Classifications

HY-145374 Related Classifications