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Cat. No.: HY-169746

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Antiviral agent 63

Antiviral agent 63 is a nucleoside analog with anti-HCV activity. Antiviral agent 63 can inhibit viral replication by inhibiting the activity of HCV RNA-dependent RNA polymerase or other virus-related enzymes.

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CAS No.: 1613591-70-0
Formule: C₂₅H₃₃F₂N₆O₈P
Masse moléculaire:614.54

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antiviral agent 63 Chemical Structure

CAS No.: 1613591-70-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

RNA Polymerase

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HeLa	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HepG2	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	>100 μM Compound: 40	Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay	[PMID: 32816483]
Huh-7	EC₅₀	0.014 μM Compound: 40	Antiviral activity against HCV con1 subgenomic replicon infected in human HuH7 cells assessed as reduction in viral RNA level by qRT-PCR analysis Antiviral activity against HCV con1 subgenomic replicon infected in human HuH7 cells assessed as reduction in viral RNA level by qRT-PCR analysis	[PMID: 32816483]
MT4	CC₅₀	92 μM Compound: 40	Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
U-937	CC₅₀	10 μM Compound: 40	Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]

Chemical Information

CAS No. 1613591-70-0
Masse moléculaire 614.54
Formule C₂₅H₃₃F₂N₆O₈P
SMILES

C[C@@]1([C@@H](O[C@@](F)([C@H]1O)COP(OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)N3C4=NC(N)=NC(OCC)=C4N=C3)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Beigelman et al, Preparation of substituted nucleosides, nucleotides and analogs thereof as antitumor and HCV antiviral agents, WO2014100505, US, 2014-06-26.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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