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Art. -Nr.: HY-126830

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Antifolate C2

Name: Antifolate C2
Brand: MedChemExpress
SKU: HY-126830
Price: 646.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1286279-90-0
Formel: C₁₉H₂₁N₅O₆S
Molecular Weight:447.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Antifolate C2 Chemical Structure

CAS. Nr.: 1286279-90-0

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
IGROV-1	IC₅₀	0.77 nM Compound: 7, AGF154	Antiproliferative activity against human IGROV1 cells after 96 hrs by CellTiter-Blue assay Antiproliferative activity against human IGROV1 cells after 96 hrs by CellTiter-Blue assay	[PMID: 26317331]
IGROV-1	IC₅₀	276 nM Compound: 7, AGF154	Antiproliferative activity against human IGROV1 cells after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid Antiproliferative activity against human IGROV1 cells after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid	[PMID: 26317331]
KB	IC₅₀	0.09 nM Compound: 7, AGF154	Antiproliferative activity against human KB cells expressing FRalpha/PCFT/RFC assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay Antiproliferative activity against human KB cells expressing FRalpha/PCFT/RFC assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay	[PMID: 26317331]
KB	IC₅₀	105 nM Compound: 7, AGF154	Antiproliferative activity against human KB cells expressing FRalpha/PCFT/RFC assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid Antiproliferative activity against human KB cells expressing FRalpha/PCFT/RFC assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid	[PMID: 26317331]
KB	IC₅₀	2.6 nM Compound: 7, AGF154	Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated for 1 hr followed by azaserine, L-glutamine, 14C(U)]-glycine addition measured after 16 hrs Inhibition of GARFTase in human KB cells expressing FRalpha/PCFT/RFC assessed as incorporation of [14C(U)]-glycine into [14C]-formyl GAR preincubated for 1 hr followed by azaserine, L-glutamine, 14C(U)]-glycine addition measured after 16 hrs	[PMID: 26317331]
R2	IC₅₀	290 nM Compound: 7, AGF154	Cytotoxicity against PCFT-null Chinese hamster R2 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay Cytotoxicity against PCFT-null Chinese hamster R2 cells assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay	[PMID: 26317331]
R2	IC₅₀	>1000 nM Compound: 7, AGF154	Cytotoxicity against Chinese hamster R2 cells transfected with empty PCDNA3 assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay Cytotoxicity against Chinese hamster R2 cells transfected with empty PCDNA3 assessed as cell growth inhibition after 96 hrs by CellTiter-Blue assay	[PMID: 26317331]
SK-OV-3	IC₅₀	15.5 nM Compound: 7, AGF154	Antiproliferative activity against human SKOV3 cells after 96 hrs by CellTiter-Blue assay Antiproliferative activity against human SKOV3 cells after 96 hrs by CellTiter-Blue assay	[PMID: 26317331]
SK-OV-3	IC₅₀	76 nM Compound: 7, AGF154	Antiproliferative activity against human SKOV3 cells after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid Antiproliferative activity against human SKOV3 cells after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid	[PMID: 26317331]

Chemical Information

CAS. Nr. 1286279-90-0
Molecular Weight 447.46
Formel C₁₉H₂₁N₅O₆S
SMILES

O=C1C2=C(NC(N)=N1)NC(CCCC3=CC(C(N[C@H](C(O)=O)CCC(O)=O)=O)=CS3)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wilson M R, et al. Targeting nonsquamous nonsmall cell lung cancer via the proton-coupled folate transporter with 6-substituted pyrrolo [2, 3-d] pyrimidine thienoyl antifolates[J]. Molecular pharmacology, 2016, 89(4): 425-434. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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