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Art. -Nr.: HY-151292

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Antitumor agent-74

Antitumor agent-74 (compound 13da) is a quinoxalines derivative, an antitumor agent. Antitumor agent-74 exhibits more potent efficacy on tumor inhibition, mixed with regioisomer Antitumor agent-75(HY-151295, compound 14 da) (mriBIQ 13da/14da). mriBIQ 13da/14da attests cell cycle at S phase, inhibits DNA synthesis, and induces mithochondrial apoptosis.

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CAS. Nr.: 2827065-28-9
Formel: C₂₆H₂₃FN₆
Molecular Weight:438.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antitumor agent-74 Chemical Structure

CAS. Nr.: 2827065-28-9

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Biologische Aktivität

Beschreibung

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen :

In Vitro

Antitumor agent-74 (compound 13da) shows lower cytotoxicity (IC₅₀s=56.7-86.3 μM) against cancer cells than mriBIQ 13da/14da (IC₅₀s=2.8-34.0 μM)^[1].
mriBIQ 13da/14da shows high selectivity on A549 cells over normal embryonic lung cells (Wi38), with selectivity index of 12 (IC₅₀ of Wi38/A549)^[1].
mriBIQ 13da/14da (1-100 μM; 48 h) inhibtis A549 cells proliferation and decreases the rate of cell division in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

M-HeLa, MCF-7, HuTu-80, PANC-1, A549, PC3, T98G, Wi38 cells
Concentration:

0-100 μM
Incubation Time:

48 hours
Result:

Showed low cytotoxicity and inhibited cancer cells with IC₅₀s of 58.7, 67.3, 75.6, 86.3, 65.6, 63.2, 68.7, and 56.7 μM, respectively.

Cell Proliferation Assay^[1]

Cell Line:

A549
Concentration:

mriBIQ 13da/14da: 1, 5, 25, 50, 100 μM
Incubation Time:

48 hours
Result:

Decreased the rate of cell division, associated with induction of apoptosis in A549 cells.

Cell Cycle Analysis^[1]

Cell Line:

A549
Concentration:

mriBIQ 13da/14da: 1, 2.5, 5 μM
Incubation Time:

12 hours
Result:

Increased the number of cells in the S-phase at 1, 2.5, and 5 μM of 49.0%, 66.3%, and 68.0%, respectively.

Chemical Information

CAS. Nr. 2827065-28-9
Molecular Weight 438.50
Formel C₂₆H₂₃FN₆
SMILES

CN1CCN(C2=CC=C3N=C(C4=CC=C(F)C=C4)C(C5=NC6=CC=CC=C6N5)=NC3=C2)CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Vakhid AM, et al. Synthesis of Morpholine-, Piperidine-, and N-Substituted Piperazine-Coupled 2-(Benzimidazol-2-yl)-3-arylquinoxalines as Novel Potent Antitumor Agents. ACS Pharmacol. Transl. Sci. 2022, XXXX, XXX, XXX-XXX.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Antitumor agent-74

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

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Chemical Information

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Antitumor agent-74 Related Classifications

HY-151292 Related Classifications