AP14145
AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect.
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- CAS. Nr.: 1446770-54-2
- Formel: C18H17F3N4O
- Molecular Weight:362.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1446770-54-2
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Molecular Weight 362.35
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Formel C18H17F3N4O
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SMILES
CC(NC1=C2C(N=C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Citerni C, et al., Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction. Front Pharmacol. 2020 May 6;11:556. [Content Brief]
[2]. Simó-Vicens R, et al., A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels. Br J Pharmacol. 2017 Dec;174(23):4396-4408. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AP14145 Related Classifications
HY-120355 Related Classifications
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