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Art. -Nr.: HY-15033

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ATB-343

ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections.

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CAS. Nr.: 1000700-26-4
Formel: C₂₈H₂₀ClNO₄S₃
Molecular Weight:566.11

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ATB-343 Chemical Structure

CAS. Nr.: 1000700-26-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	3294.4 μM Compound: 15	Cytotoxicity against human HepG2 cells assessed as reduction in cell survival after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell survival after 24 hrs by MTT assay	[PMID: 28646655]
L02	IC₅₀	337.2 μM Compound: 15	Cytotoxicity against human LO2 cells assessed as reduction in cell survival after 24 hrs by MTT assay Cytotoxicity against human LO2 cells assessed as reduction in cell survival after 24 hrs by MTT assay	[PMID: 28646655]

Chemical Information

CAS. Nr. 1000700-26-4
Molecular Weight 566.11
Formel C₂₈H₂₀ClNO₄S₃
SMILES

O=C(CC1=C(C)N(C(C2=CC=C(C=C2)Cl)=O)C3=C1C=C(C=C3)OC)OC4=CC=C(C(SS5)=CC5=S)C=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li M, et al. Syntheses, toxicities and anti-inflammation of H2S-donors based on non-steroidal anti-inflammatory drugs. Eur J Med Chem. 2017 Sep 29;138:51-65. [Content Brief]

[2]. Methods for treating viral infections using hydrogen sulfide (H2S) donors. United States, US20160058779 A1 2016-03-03.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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ATB-343

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Biologische Aktivität

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ATB-343 Related Classifications

HY-15033 Related Classifications