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Art. -Nr.: HY-183076

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AW00718

AW00718 is a Brachyspira pilosicoli glutamate racemase (Bp-MurI) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro. AW00718 can be used for the research of intestinal spirochaetosis.

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CAS. Nr.: 215778-00-0
Formel: C₁₇H₁₃BrN₄S
Molecular Weight:385.28

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AW00718 Chemical Structure

CAS. Nr.: 215778-00-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

AW00718 forms a stable complex with homology-modelled Brachyspira pilosicoli glutamate racemase (Bp-MurI)^[1].
AW00718 (5 days) inhibits the growth of Brachyspira pilosicoli strain BP2904 in vitro with a MIC₅₀ of 0.25 mM and a MIC₁₀₀ of 0.5 mM^[1].
AW00718 (1 mM; 24 h) causes ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 24 hours of treatment and 6 hours of Resazurin (HY-118540) exposure, with no cytotoxicity detected after 24 hours of Resazurin exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human Chang conjunctival epithelial cells
Concentration:

1 mM
Incubation Time:

24 h following6 h (Resazurin exposure); 24 h (Resazurin exposure single)
Result:

Induced ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 6 hours of Resazurin exposure.
Caused 0% cytotoxicity after 24 hours of resazurin single exposure.

Chemical Information

CAS. Nr. 215778-00-0
Molecular Weight 385.28
Formel C₁₇H₁₃BrN₄S
SMILES

BrC1=CC=C(NC2=C3N=NC(SCC4=CC=C(C)C=C4)=N2)C3=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kant R, et al. Identification of small molecule inhibitors for the Brachyspira pilosicoli glutamate racemase (Bp-MurI) enzyme using a computational and experimental approach. Sci Rep. 2026 Apr 2. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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