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Art. -Nr.: HY-123572

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Bis-T-23

(Synonyms: AG1717)

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Based on 1 Customer Validation

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 96.07%
CAS. Nr.: 171674-76-3
Formel: C₂₃H₂₀N₄O₈
Molecular Weight:480.43

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Bis-T-23 Chemical Structure

CAS. Nr.: 171674-76-3

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Bis-T-23 (AG1717) (0.18 μM) can inhibit HIV-1 integrase^[2].
AG1717 (2 μM) can inhibit binding of integrase to the substrate DNA^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bis-T-23 (AG1717) (1 ng) targets actin-dependent dynamin oligomerization in podocytes to promote proper GFB function^[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorate proteinuria by altering actin dynamics^[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorates or prevented proteinuria and diminished mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (8 weeks old, males); Mice^[1]
Dosage:

20, 40 mg/kg; 40 mg/kg
Administration:

Intraperitoneal injection; signle, once for 6 consecutive days
Result:

Specifically reduced proteinuria on days 18 and 24.
Caused a transient reduction of proteinuria (single dose) in PKCε^KO mice.
Completely prevented the onset of high-level proteinuria in the CD2AP^KO mice.
Significantly extended the lifespans of CD2AP^KO mice.
Led to improved glomerular histology with less mesangial matrix accumulation.

Animal Model:

Zebrafish^[1]
Dosage:

1 ng
Administration:

Injection
Result:

Promoted oligomerization of zebrafish Dyn2.
Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes.

Chemical Information

CAS. Nr. 171674-76-3
Appearance Solid
Molecular Weight 480.43
Formel C₂₃H₂₀N₄O₈
Color Light yellow to yellow
SMILES

O=C(/C(C#N)=C/C1=CC(O)=C(C(O)=C1)O)NCCCNC(/C(C#N)=C/C2=CC(O)=C(C(O)=C2)O)=O
Synonyms

AG1717
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (208.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0815 mL

10.4073 mL

20.8147 mL

5 mM

0.4163 mL

2.0815 mL

4.1629 mL

10 mM

0.2081 mL

1.0407 mL

2.0815 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Schiffer M, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21(6):601-609. [Content Brief]

[2]. Mazumder, A.,et al. Effects of Tyrphostins, Protein Kinase Inhibitors, on Human Immunodeficiency Virus Type 1 Integrase. Biochemistry, 1995, 34(46), 15111–15122.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0815 mL	10.4073 mL	20.8147 mL	52.0367 mL
	5 mM	0.4163 mL	2.0815 mL	4.1629 mL	10.4073 mL
	10 mM	0.2081 mL	1.0407 mL	2.0815 mL	5.2037 mL
	15 mM	0.1388 mL	0.6938 mL	1.3876 mL	3.4691 mL
	20 mM	0.1041 mL	0.5204 mL	1.0407 mL	2.6018 mL
	25 mM	0.0833 mL	0.4163 mL	0.8326 mL	2.0815 mL
	30 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7346 mL
	40 mM	0.0520 mL	0.2602 mL	0.5204 mL	1.3009 mL
	50 mM	0.0416 mL	0.2081 mL	0.4163 mL	1.0407 mL
	60 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8673 mL
	80 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6505 mL
	100 mM	0.0208 mL	0.1041 mL	0.2081 mL	0.5204 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
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Bis-T-23

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Covalent Screening Library

Cytoskeleton Compound Library

Protein-protein Interaction Inhibitor Library

Metabolic Enzyme Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bis-T-23

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

Covalent Screening Library

Cytoskeleton Compound Library

Protein-protein Interaction Inhibitor Library

Metabolic Enzyme Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

Covalent Screening Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bis-T-23 Related Classifications

HY-123572 Related Classifications