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Art. -Nr.: HY-178987

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BJH-86

BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC₅₀ = 5 μM). BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC₅₀ >10 μM). BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer.

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CAS. Nr.: 3067849-10-6
Formel: C₂₃H₂₁N₃O₂
Molecular Weight:371.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

BJH-86 Chemical Structure

CAS. Nr.: 3067849-10-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

PDE10A

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen :

In Vitro

BJH-86 (1-10 μM, 30 min-96 h) potently inhibits mitochondrial complex I (oxygen consumption rate inhibition IC₅₀ = 5 μM) in A549 human lung cancer cells and EO771 murine breast cancer cells^[1].
BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A, IC₅₀ >10 μM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BJH-86 (2-30 mg/kg, i.v.) inhibits tumor growth in C57Bl6 mice bearing EO771 xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57Bl6 mice bearing EO771 xenografts^[1]
Dosage:

2 mg/kg single dose 1 h before radiotherapy and 30 mg/kg repeated administration
Administration:

Intravenously injection
Result:

Reduced tumor hypoxia.
Enhanced radiosensitivity (5 Gy) .
Prolonged tumor growth delay from 2 days to 4 days.

Chemical Information

CAS. Nr. 3067849-10-6
Molecular Weight 371.43
Formel C₂₃H₂₁N₃O₂
SMILES

COC1=CC=C2N=CC=C(CC3=CC=CC(C4=CN(C5COC5)N=C4)=C3)C2=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Haines BJ, et al. Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer. J Med Chem. 2025 Oct 19. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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BJH-86

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

BJH-86 Related Classifications

HY-178987 Related Classifications