BMS-929075
BMS-929075 is a potent and orally active HCV NS5B replicase palm site allosteric inhibitor. BMS-929075 shows high oral bioavailability. BMS-929075 shows cytotoxicity.
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- CAS. Nr.: 1217338-97-0
- Formel: C31H24F2N4O3
- Molecular Weight:538.54
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | CC50 |
>50 μM
Compound: 37; BMS-929075
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Cytotoxicity against primary human hepatocytes
Cytotoxicity against primary human hepatocytes
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[PMID: 28430437] |
| HepG2 | CC50 |
>12.5 μM
Compound: 37; BMS-929075
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Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
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[PMID: 28430437] |
| Huh-7 | CC50 |
60 μM
Compound: 37; BMS-929075
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Cytotoxicity against human HuH7 cells after 3 days by CellTiter-Blue assay
Cytotoxicity against human HuH7 cells after 3 days by CellTiter-Blue assay
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[PMID: 28430437] |
BMS-929075 (0-60 µM) shows cytotoxicity with CC50 values of 60, >12.5, >50 µM for Huh-7, HepG2, primary human hepatocytes, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Parameters of BMS-929075 in Male Sprague-Dawley rats[1].
| IV | PO | |||||||||
| species | Cl (mL/min/kg) | IV t1/2(hr) | Vss(L/kg) | Cmax(µM) | Tmax(hr) | AUC (µM h) | C6 liver (µM) | C24 liver (µM) | C24 liver/plasma (µM) | F% (mL/min/kg) |
| rat | 1.7 | 4.7 | 0.7 | 7.5 | 4 | 54.5 | 15.1 | 1.12 | 1.6 | 48 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1217338-97-0
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Molecular Weight 538.54
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Formel C31H24F2N4O3
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SMILES
O=C(C1=CC(C2=C(F)C3=C(OC(C4=CC=C(F)C=C4)=C3C(NC)=O)C=C2)=C(C)C=C1)NC5(CC5)C6=NC=CC=N6
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BMS-929075 Related Classifications
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