BMY 45778
Based on 1 Customer Validation
BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC50 = 35 nM), rabbit (IC50: 136 nM) and rat (IC50 : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.98%
- CAS. Nr.: 152575-66-1
- Formel: C26H18N2O5
- Molecular Weight:438.43
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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- Verweise
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | EC50 |
27 nM
Compound: 48
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Anti-platelet activity in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
Anti-platelet activity in human platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation
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[PMID: 21413808] |
| Platelet | EC50 |
27 nM
Compound: 48
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Anti-platelet activity in human platelet-rich plasma assessed as inhibition of collagen-induced platelet aggregation
Anti-platelet activity in human platelet-rich plasma assessed as inhibition of collagen-induced platelet aggregation
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[PMID: 21413808] |
Chemical Information
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CAS. Nr. 152575-66-1
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Appearance Solid
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Molecular Weight 438.43
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Formel C26H18N2O5
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Color White to light yellow
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SMILES
O=C(O)COC1=CC=CC(C2=C(C3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)N=CO2)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (114.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Seiler SM, et al. [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins. 1997 Jan;53(1):21-35. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2809 mL | 11.4043 mL | 22.8087 mL | 57.0216 mL |
| 5 mM | 0.4562 mL | 2.2809 mL | 4.5617 mL | 11.4043 mL | |
| 10 mM | 0.2281 mL | 1.1404 mL | 2.2809 mL | 5.7022 mL | |
| 15 mM | 0.1521 mL | 0.7603 mL | 1.5206 mL | 3.8014 mL | |
| 20 mM | 0.1140 mL | 0.5702 mL | 1.1404 mL | 2.8511 mL | |
| 25 mM | 0.0912 mL | 0.4562 mL | 0.9123 mL | 2.2809 mL | |
| 30 mM | 0.0760 mL | 0.3801 mL | 0.7603 mL | 1.9007 mL | |
| 40 mM | 0.0570 mL | 0.2851 mL | 0.5702 mL | 1.4255 mL | |
| 50 mM | 0.0456 mL | 0.2281 mL | 0.4562 mL | 1.1404 mL | |
| 60 mM | 0.0380 mL | 0.1901 mL | 0.3801 mL | 0.9504 mL | |
| 80 mM | 0.0285 mL | 0.1426 mL | 0.2851 mL | 0.7128 mL | |
| 100 mM | 0.0228 mL | 0.1140 mL | 0.2281 mL | 0.5702 mL |
BMY 45778 Related Classifications
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