BPIPP
Based on 1 Customer Validation
BPIPP is a guanylyl cyclase type C (GC-C) and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.3%
- CAS. Nr.: 325746-94-9
- Formel: C22H16BrN3O3
- Molecular Weight:450.28
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| T84 | IC50 |
3.4 μM
Compound: 1, BPIPP
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Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 100 nM toxin challenge measured after 10 mins of induction by ELISA
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 100 nM toxin challenge measured after 10 mins of induction by ELISA
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[PMID: 19409779] |
| T84 | IC50 |
9.6 μM
Compound: 1, BPIPP
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Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 1 nM toxin challenge measured after 10 mins of induction by ELISA
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 1 nM toxin challenge measured after 10 mins of induction by ELISA
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[PMID: 19409779] |
BPIPP suppresses stable toxin (STa)-stimulated cGMP accumulation by decreasing GC-C activation in intact T84 human colorectal carcinoma cells. BPIPP inhibits stimulation of guanylyl cyclases, including types A and B and soluble isoform in various cells. BPIPP suppresses stimulation of adenylyl cyclase and significantly decreases the activities of adenylyl cyclase toxin of Bordetella pertussis and edema toxin of Bacillus anthracis. The effects of BPIPP on cyclic nucleotide synthesis were observed only in intact cells[1].
BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases and suppressed STa-induced fluid accumulation in an in vivo rabbit intestinal loop model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 325746-94-9
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Appearance Solid
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Molecular Weight 450.28
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Formel C22H16BrN3O3
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Color Orange to red
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SMILES
O=C1C2=C(C3=CC=CC=C13)NC(N(C(N(C)C4=O)=O)C)=C4C2C5=CC(Br)=CC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BPIPP Related Classifications
HY-107547 Related Classifications
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