BTA-1_b
Based on 1 Customer Validation
BTA-1_b (BTA-1-CH3) is a structural analog of BTA-1 (HY-W278021). BTA-1 is an uncharged derivative of Thioflavin-T. It exhibits high affinity for Aβ fibrils and demonstrates excellent brain penetration and clearance capabilities.
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- CAS. Nr.: 95856-73-8
- Formel: C15H14N2S
- Molecular Weight:254.35
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
Chemical Information
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CAS. Nr. 95856-73-8
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Appearance Solid
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Molecular Weight 254.35
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Formel C15H14N2S
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SMILES
CNC1=CC=C(C=C1)C2=NC3=CC=C(C=C3S2)C
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Synonyms
BTA-1-CH3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 5.56 mg/mL (21.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
[1]. Tomoshige S, et al. Discovery of Small Molecules that Induce the Degradation of Huntingtin. Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11530-11533. [Content Brief]
[2]. Wu C, et. al. The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations. J Mol Biol. 2008 Dec 19;384(3):718-29. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9316 mL | 19.6580 mL | 39.3159 mL | 98.2898 mL |
| 5 mM | 0.7863 mL | 3.9316 mL | 7.8632 mL | 19.6580 mL | |
| 10 mM | 0.3932 mL | 1.9658 mL | 3.9316 mL | 9.8290 mL | |
| 15 mM | 0.2621 mL | 1.3105 mL | 2.6211 mL | 6.5527 mL | |
| 20 mM | 0.1966 mL | 0.9829 mL | 1.9658 mL | 4.9145 mL |
BTA-1_b Related Classifications
HY-151035 Related Classifications
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