313669-88-4
Chemical Structure
BMS-986122
- CAS. Nr.: 313669-88-4
- Formula:C16H15BrClNO3S2
- Molecular Weight:448.78
IUPAC Name: 2-(3-bromo-4-methoxyphenyl)-3-((4-chlorophenyl)sulfonyl)thiazolidine
InChIKey: PNGJPVDGZNPZHY-UHFFFAOYSA-N
SMILES: O=S(N1C(C2=CC=C(OC)C(Br)=C2)SCC1)(C3=CC=C(Cl)C=C3)=O
Biological Activity: BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes[1][2].
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BMS-986122 | 99.90% | BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes. | ||||||||||||||||||||
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- [1]. Burford NT, et al. Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor. Proc Natl Acad Sci U S A. 2013;110(26):10830-10835. [Content Brief]
- [2]. Kandasamy R, et al. Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proc Natl Acad Sci U S A. 2021;118(16):e2000017118. [Content Brief]
Keywords
