Clamikalant
Clamikalant (HMR 1098 free base) is a compound used to suppress cardiac arrhythmias. It prevents the reduction of the refractory period during ventricular fibrillation in dogs and also shows antiarrhythmic effects in a rabbit heart model.
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- CAS. Nr.: 158751-64-5
- Formel: C19H22ClN3O5S2
- Molecular Weight:471.98
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Beschreibung
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
8.2 μM
Compound: 33 HMR-1883
|
Inhibition of human SUR1/Kir6.2 expressed in CHO cells
Inhibition of human SUR1/Kir6.2 expressed in CHO cells
|
[PMID: 11356099] |
| Oocyte | IC50 |
4.3 μM
Compound: 33 HMR-1883
|
Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes
Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytes
|
[PMID: 11356099] |
Chemical Information
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CAS. Nr. 158751-64-5
-
Molecular Weight 471.98
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Formel C19H22ClN3O5S2
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SMILES
O=C(NCCC1=CC=C(OC)C(S(=O)(NC(NC)=S)=O)=C1)C2=CC(Cl)=CC=C2OC
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Synonyms
HMR 1098 free base
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)