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Art. -Nr.: HY-N18312

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Crepidatin

Crepidatin is a bibenzyl compound that can be isolated from the stems of Dendrobium loddigesii. Crepidatin promotes anoikis of lung cancer cells. Crepidatin inhibits the anchorage-independent growth of human lung cancer cells. Crepidatin can be used in lung cancer-related research.

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CAS. Nr.: 101508-50-3
Formel: C₁₈H₂₂O₅
Molecular Weight:318.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Crepidatin Chemical Structure

CAS. Nr.: 101508-50-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H23	IC₅₀	157.77 μM Compound: 12	Anti-cancer activity against human NCI-H23 cells Anti-cancer activity against human NCI-H23 cells	[PMID: 32711292]

In Vitro

Crepidatin (Compound 3) exhibits cytotoxic activity against H23 cells after 24 h, with an IC₅₀ value of 157.77 μM^[1].
Crepidatin (0-1 μM; 24 h) significantly enhances anoikis in H23 cells^[1].
Crepidatin (0-1 μM; 4 weeks) significantly inhibits the anchorage-independent growth of H23 cells by reducing colony number and diameter^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

H23 cells
Concentration:

0, 0.5, 1 μM
Incubation Time:

4 weeks (suspended soft agar culture)
Result:

Significantly reduced relative colony numbe and relative colony diamete compared to untreated control.
Further reduced relative colony number nd relative colony diameter compared to untreated control at 1 μM.

Apoptosis Analysis^[1]

Cell Line:

H23 cells
Concentration:

0, 0.5, 1 μM
Incubation Time:

24 h
Result:

Caused significant enhancing effect on cell anoikis in a concentration-dependent manner.

Chemical Information

CAS. Nr. 101508-50-3
Molecular Weight 318.36
Formel C₁₈H₂₂O₅
SMILES

OC1=CC=C(CCC2=CC(OC)=C(C(OC)=C2)OC)C=C1OC
Structure Classification
- Phenols
- Monophenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chanvorachote P, et al. Anti-metastatic activities of bibenzyls from Dendrobium pulchellum. Nat Prod Commun. 2013;8(1):115-118. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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